PrimePCR™ ddPCR™ Expression Probe Assay: HNRNPA1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0057966; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5045243
Chromosome Location:   12:54678547-54678734question
Amplicon Length:   158

Gene Information

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein along with other hnRNP proteins is exported from the nucleus probably bound to mRNA and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq Jul 2008]

Gene Symbol:   HNRNPA1
Gene Name:   heterogeneous nuclear ribonucleoprotein A1
Aliases:   HNRPA1, HNRPA1L3, MGC102835, hnRNP A1, hnRNP-A1
RefSeq:   NC_000012.11 NT_029419.12
Ensembl:   ENSG00000135486
Entrez:   3178
UniGene:   Hs.546261
Chromosome Mapping:   12q13.1

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