This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0057821; exonic
Granulins are a family of secreted glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein progranulin is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active 6 kDa peptides. These smaller cleavage products are named granulin A granulin B granulin C etc. Epithelins 1 and 2 are synonymous with granulins A and B respectively. Both the peptides and intact granulin protein regulate cell growth. However different members of the granulin protein family may act as inhibitors stimulators or have dual actions on cell growth. Granulin family members are important in normal development wound healing and tumorigenesis. [provided by RefSeq Jul 2008]