PrimePCR™ ddPCR™ Expression Probe Assay: IL4R, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0057752; exonic

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5044962
Chromosome Location:   16:27375473-27375614question
Amplicon Length:   112

Gene Information

This gene encodes the alpha chain of the interleukin-4 receptor a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy a condition that can manifest itself as allergic rhinitis sinusitus asthma or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq Apr 2012]

Gene Symbol:   IL4R
Gene Name:   interleukin 4 receptor
Aliases:   CD124, IL4RA
RefSeq:   NC_000016.9 NG_012086.1 NT_010393.16
Ensembl:   ENSG00000077238
Entrez:   3566
UniGene:   Hs.513457
Chromosome Mapping:   16p12.1-p11.2

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