PrimePCR™ ddPCR™ Expression Probe Assay: RAG2, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0057705; exonic

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5044879
Chromosome Location:   11:36616398-36616544question
Amplicon Length:   117

Gene Information

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1 and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq Jul 2008]

Gene Symbol:   RAG2
Gene Name:   recombination activating gene 2
Aliases:   RAG-2
RefSeq:   NC_000011.9 NG_007573.1 NT_009237.18
Ensembl:   ENSG00000175097
Entrez:   5897
UniGene:   Hs.714519
Chromosome Mapping:   11p13

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