PrimePCR™ ddPCR™ Expression Probe Assay: SREBF1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0057685; exonic

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5044842
Chromosome Location:   17:17721598-17722333question
Amplicon Length:   68

Gene Information

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1) which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor and the mature nuclear form is rapidly catabolized thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   SREBF1
Gene Name:   sterol regulatory element binding transcription factor 1
Aliases:   SREBP-1c, SREBP1, bHLHd1
RefSeq:   NC_000017.10 NG_007101.2 NT_010718.16
Ensembl:   ENSG00000072310
Entrez:   6720
UniGene:   Hs.592123
Chromosome Mapping:   17p11.2

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