PrimePCR™ ddPCR™ Expression Probe Assay: GSTA2, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0056062; exonic

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5044277
Chromosome Location:   6:52615089-52615234question
Amplicon Length:   116

Gene Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds including carcinogens therapeutic drugs environmental toxins and products of oxidative stress by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha kappa mu omega pi sigma theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes located in a cluster mapped to chromosome 6 are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq Jul 2008]

Gene Symbol:   GSTA2
Gene Name:   glutathione S-transferase alpha 2
Aliases:   GST2, GSTA2-2, GTA2, GTH2, MGC10525
RefSeq:   NC_000006.11 NT_007592.15
Ensembl:   ENSG00000244067
Entrez:   2939
UniGene:   Hs.94107
Chromosome Mapping:   6p12.1

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