PrimePCR™ ddPCR™ Expression Probe Assay: UGT1A1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0056033; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5044224
Chromosome Location:   2:234669350-234669467question
Amplicon Length:   88

Gene Information

This gene encodes a UDP-glucuronosyltransferase an enzyme of the glucuronidation pathway that transforms small lipophilic molecules such as steroids bilirubin hormones and drugs into water-soluble excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin although it also has moderate activity with simple phenols flavones and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq Jul 2008]

Gene Symbol:   UGT1A1
Gene Name:   UDP glucuronosyltransferase 1 family, polypeptide A1
Aliases:   BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
RefSeq:   NC_000002.11 NG_002601.2 NG_009254.1 NT_005120.16
Ensembl:   ENSG00000241635
Entrez:   54658
UniGene:   Hs.554822
Chromosome Mapping:   2q37

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