PrimePCR™ ddPCR™ Expression Probe Assay: E2F4, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0055756; exonic

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5043740
Chromosome Location:   16:67228877-67229770question
Amplicon Length:   63

Gene Information

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP) a transactivation domain enriched in acidic amino acids and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB p107 and p130 but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq Jul 2008]

Gene Symbol:   E2F4
Gene Name:   E2F transcription factor 4, p107/p130-binding
Aliases:   E2F-4
RefSeq:   NC_000016.9 NT_010498.15
Ensembl:   ENSG00000205250
Entrez:   1874
UniGene:   Hs.108371
Chromosome Mapping:   16q21-q22

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