PrimePCR™ ddPCR™ Expression Probe Assay: CR1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0055672; exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5043597
Chromosome Location:   1:207680157-207696960question
Amplicon Length:   63

Gene Information

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes leukocytes glomerular podocytes and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas mesangiocapillary glomerulonephritis systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms have been characterized. Additional allele specific isoforms including a secreted form have been described but have not been fully characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   CR1
Gene Name:   complement component (3b/4b) receptor 1 (Knops blood group)
Aliases:   C3BR, C4BR, CD35, KN
RefSeq:   NC_000001.10 NG_007481.1 NT_167186.1
Ensembl:   ENSG00000203710
Entrez:   1378
UniGene:   Hs.334019
Chromosome Mapping:   1q32

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