This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0054298; exonic
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways mediating cellular proliferation survival and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues thus may function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway and knockout mice have been shown to develop spontaneous tumors suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Oct 2011]