PrimePCR™ ddPCR™ Expression Probe Assay: UPF3A, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053865; exonic

 
Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5040376
Chromosome Location:   13:115070842-115070979question
Amplicon Length:   108

Gene Information

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   UPF3A
Gene Name:   UPF3 regulator of nonsense transcripts homolog A (yeast)
Aliases:   FLJ35267, FLJ57970, HUPF3A, RENT3A, UPF3
RefSeq:   NC_000013.10 NT_024498.12
Ensembl:   ENSG00000169062
Entrez:   65110
UniGene:   Hs.533855
Chromosome Mapping:   13q34

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