PrimePCR™ ddPCR™ Expression Probe Assay: KLKB1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0053474; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039649
Chromosome Location:   4:187149406-187153408question
Amplicon Length:   100

Gene Information

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation fibrinolysis kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq Jul 2008]

Gene Symbol:   KLKB1
Gene Name:   kallikrein B, plasma (Fletcher factor) 1
Aliases:   KLK3, PPK
RefSeq:   NC_000004.11 NG_012095.1 NT_016354.19
Ensembl:   ENSG00000164344
Entrez:   3818
UniGene:   Hs.237642
Chromosome Mapping:   4q35

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