PrimePCR™ ddPCR™ Expression Probe Assay: TLR3, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053473; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039646
Chromosome Location:   4:187003545-187003664question
Amplicon Length:   90

Gene Information

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   TLR3
Gene Name:   toll-like receptor 3
Aliases:   CD283
RefSeq:   NC_000004.11 NG_007278.1 NT_016354.19
Ensembl:   ENSG00000164342
Entrez:   7098
UniGene:   Hs.657724
Chromosome Mapping:   4q35

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