PrimePCR™ ddPCR™ Expression Probe Assay: HAAO, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053282; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039302
Chromosome Location:   2:42994233-42994329question
Amplicon Length:   67

Gene Information

3-Hydroxyanthranilate 34-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs such as liver and kidney and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq Jul 2008]

Gene Symbol:   HAAO
Gene Name:   3-hydroxyanthranilate 3,4-dioxygenase
Aliases:   3-HAO, HAO
RefSeq:   NC_000002.11 NT_022184.15
Ensembl:   ENSG00000162882
Entrez:   23498
UniGene:   Hs.368805
Chromosome Mapping:   2p21

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