PrimePCR™ ddPCR™ Expression Probe Assay: ALPL, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0053252; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039245
Chromosome Location:   1:21902302-21902392question
Amplicon Length:   61

Gene Information

There are at least four distinct but related alkaline phosphatases: intestinal placental placental-like and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is therefore referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary however depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq Apr 2010]

Gene Symbol:   ALPL
Gene Name:   alkaline phosphatase, liver/bone/kidney
Aliases:   AP-TNAP, APTNAP, FLJ40094, FLJ93059, HOPS, MGC161443, MGC167935, TNAP, TNSALP
RefSeq:   NC_000001.10 NG_008940.1 NT_004610.19
Ensembl:   ENSG00000162551
Entrez:   249
UniGene:   Hs.75431
Chromosome Mapping:   1p36.12

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