PrimePCR™ ddPCR™ Expression Probe Assay: FGFR4, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053176; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039110
Chromosome Location:   5:176516563-176517399question
Amplicon Length:   111

Gene Information

The protein encoded by this gene is a member of the fibroblast growth factor receptor family where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation. The genomic organization of this gene compared to members 1-3 encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and although its specific function is unknown it is overexpressed in gynecological tumor samples suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq Jul 2008]

Gene Symbol:   FGFR4
Gene Name:   fibroblast growth factor receptor 4
Aliases:   CD334, JTK2, MGC20292, TKF
RefSeq:   NC_000005.9 NT_023133.13 NG_012067.1
Ensembl:   ENSG00000160867
Entrez:   2264
UniGene:   Hs.165950
Chromosome Mapping:   5q35.1-qter

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