PrimePCR™ ddPCR™ Expression Probe Assay: CCR5, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053173; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039104
Chromosome Location:   3:46414400-46414504question
Amplicon Length:   75

Gene Information

This gene encodes a member of the beta chemokine receptor family which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages and is known to be an important co-receptor for macrophage-tropic virus including HIV to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2) macrophage inflammatory protein 1 alpha (MIP-1 alpha) macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   CCR5
Gene Name:   chemokine (C-C motif) receptor 5
Aliases:   CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, FLJ78003, IDDM22
RefSeq:   NC_000003.11 NG_012637.1 NT_022517.18
Ensembl:   ENSG00000160791
Entrez:   1234
UniGene:   Hs.450802
Chromosome Mapping:   3p21.31

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