This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0053151; exonic
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however this gene is located at 21q22.3. This protein may function in Neurite extension proliferation of melanoma cells stimulation of Ca2+ fluxes inhibition of PKC-mediated phosphorylation astrocytosis and axonal proliferation and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological neoplastic and other types of diseases including Alzheimer's disease Down's syndrome epilepsy amyotrophic lateral sclerosis melanoma and type I diabetes. [provided by RefSeq Jul 2008]