PrimePCR™ ddPCR™ Expression Probe Assay: MMP14, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053026; exonic

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5038836
Chromosome Location:   14:23305838-23305935question
Amplicon Length:   68

Gene Information

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development reproduction and tissue remodeling as well as in disease processes such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein and this activity may be involved in tumor invasion. [provided by RefSeq Jul 2008]

Gene Symbol:   MMP14
Gene Name:   matrix metallopeptidase 14 (membrane-inserted)
Aliases:   MMP-X1, MT1-MMP, MTMMP1
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000157227
Entrez:   4323
UniGene:   Hs.2399
Chromosome Mapping:   14q11-q12

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