PrimePCR™ ddPCR™ Expression Probe Assay: RANBP2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0052856; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5038529
Chromosome Location:   2:109400820-109400952question
Amplicon Length:   103

Gene Information

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that for some substrates modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq Jul 2008]

Gene Symbol:   RANBP2
Gene Name:   RAN binding protein 2
Aliases:   ANE1, NUP358, TRP1, TRP2
RefSeq:   NC_000002.11 NG_012210.1 NT_022171.15
Ensembl:   ENSG00000153201
Entrez:   5903
UniGene:   Hs.199561
Chromosome Mapping:   2q12.3

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