PrimePCR™ ddPCR™ Expression Probe Assay: DAB2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0052852; exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5038523
Chromosome Location:   5:39394394-39394483question
Amplicon Length:   60

Gene Information

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2 an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras) via its C-terminal proline-rich sequences and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Oct 2011]

Gene Symbol:   DAB2
Gene Name:   disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Aliases:   DOC-2, DOC2, FLJ26626
RefSeq:   NC_000005.9 NT_006576.16
Ensembl:   ENSG00000153071
Entrez:   1601
UniGene:   Hs.696631
Chromosome Mapping:   5p13

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