PrimePCR™ ddPCR™ Expression Probe Assay: RAD17, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0052847; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5038512
Chromosome Location:   5:68709884-68710028question
Amplicon Length:   115

Gene Information

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17 a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC) and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene which encode four distinct proteins have been reported. Two pseudogenes located on chromosomes 7 and 13 have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   RAD17
Gene Name:   RAD17 homolog (S. pombe)
Aliases:   CCYC, FLJ41520, HRAD17, R24L, RAD17SP, RAD24
RefSeq:   NC_000005.9 NG_017201.1 NT_006713.15 NW_003315917.1
Ensembl:   ENSG00000152942
Entrez:   5884
UniGene:   Hs.16184
Chromosome Mapping:   5q13

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