PrimePCR™ ddPCR™ Expression Probe Assay: INCENP, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0052714; exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5038295
Chromosome Location:   11:61896328-61897326question
Amplicon Length:   71

Gene Information

In mammalian cells 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger' or transiently interacting proteins (reviewed by Choo 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139) CENPB (MIM 117140) CENPC1 (MIM 117141) and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g. MIM 600112); CliPs (e.g. MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke 1991 [PubMed 1860899]) the initial members of the passenger protein group display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase the proteins are located within the midbody in the intercellular bridge where they are discarded after cytokinesis (Cutts et al. 1999 [PubMed 10369859]).[supplied by OMIM Mar 2008]

Gene Symbol:   INCENP
Gene Name:   inner centromere protein antigens 135/155kDa
Aliases:   FLJ31633, MGC111393
RefSeq:   NC_000011.9 NT_167190.1
Ensembl:   ENSG00000149503
Entrez:   3619
UniGene:   Hs.142179
Chromosome Mapping:   11q12.3

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