PrimePCR™ ddPCR™ Expression Probe Assay: CDKN2B, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0052653; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5038187
Chromosome Location:   9:22008981-22009095question
Amplicon Length:   85

Gene Information

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor which forms a complex with CDK4 or CDK6 and prevents the activation of the CDK kinases thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene which encode distinct proteins have been reported. [provided by RefSeq Jul 2008]

Gene Symbol:   CDKN2B
Gene Name:   cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Aliases:   CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
RefSeq:   NC_000009.11 NT_008413.18 NG_023297.1
Ensembl:   ENSG00000147883
Entrez:   1030
UniGene:   Hs.72901
Chromosome Mapping:   9p21

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