PrimePCR™ ddPCR™ Expression Probe Assay: RFX5, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0052387; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5037704
Chromosome Location:   1:151318805-151319057question
Amplicon Length:   75

Gene Information

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B C and D all lead to a deficiency in RFX a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al. 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq Jul 2008]

Gene Symbol:   RFX5
Gene Name:   regulatory factor X, 5 (influences HLA class II expression)
Aliases:   Not Available
RefSeq:   NC_000001.10 NG_007576.1 NT_004487.19
Ensembl:   ENSG00000143390
Entrez:   5993
UniGene:   Hs.632472
Chromosome Mapping:   1q21

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