PrimePCR™ ddPCR™ Expression Probe Assay: ERBB2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0052301; exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5037555
Chromosome Location:   17:37872848-37873669question
Amplicon Length:   78

Gene Information

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported with the most common allele Ile654/Ile655 shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers including breast and ovarian tumors. Alternative splicing results in several additional transcript variants some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   ERBB2
Gene Name:   v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Aliases:   CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
RefSeq:   NC_000017.10 NT_010783.15 NG_007503.1
Ensembl:   ENSG00000141736
Entrez:   2064
UniGene:   Hs.446352
Chromosome Mapping:   17q11.2-q12,17q21.1

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