PrimePCR™ ddPCR™ Expression Probe Assay: CCM2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051947; exonic

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5036934
Chromosome Location:   7:45115444-45115539question
Amplicon Length:   66

Gene Information

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure cell-cell interactions and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq Nov 2009]

Gene Symbol:   CCM2
Gene Name:   cerebral cavernous malformation 2
Aliases:   C7orf22, MGC4067, MGC4607, MGC74868, OSM
RefSeq:   NC_000007.13 NT_007819.17 NG_016295.1
Ensembl:   ENSG00000136280
Entrez:   83605
UniGene:   Hs.148272
Chromosome Mapping:   7p13

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