PrimePCR™ ddPCR™ Expression Probe Assay: MDM2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051885; exonic

Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5036818
Chromosome Location:   12:69233407-69233529question
Amplicon Length:   93

Gene Information

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53 as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53 diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle apoptosis and tumorigenesis through interactions with other proteins including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq Jul 2008]

Gene Symbol:   MDM2
Gene Name:   Mdm2 p53 binding protein homolog (mouse)
Aliases:   HDMX, MGC5370, MGC71221, hdm2
RefSeq:   NC_000012.11 NG_016708.1 NT_029419.12
Ensembl:   ENSG00000135679
Entrez:   4193
UniGene:   Hs.484551
Chromosome Mapping:   12q14.3-q15

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