PrimePCR™ ddPCR™ Expression Probe Assay: IMPA1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051768; exonic

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5036606
Chromosome Location:   8:82592898-82593736question
Amplicon Length:   95

Gene Information

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol a precursor of phosphatidylinositol and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 145-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-13-diphosphate myo-inositol-14-diphosphate scyllo-inositol-phosphate glucose-1-phosphate glucose-6-phosphate fructose-1-phosphate beta-glycerophosphate and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq Nov 2009]

Gene Symbol:   IMPA1
Gene Name:   inositol(myo)-1(or 4)-monophosphatase 1
Aliases:   IMP, IMPA
RefSeq:   NC_000008.10 NG_015829.1 NT_008183.19
Ensembl:   ENSG00000133731
Entrez:   3612
UniGene:   Hs.656694
Chromosome Mapping:   8q21.13-q21.3

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