PrimePCR™ ddPCR™ Expression Probe Assay: LPIN3, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051731; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5036544
Chromosome Location:   20:39984536-39985680question
Amplicon Length:   110

Gene Information

Humans lipodystrophy is characterized by loss of body fat fatty liver hypertriglyceridemia and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1 LPIN2 and LPIN3). Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12 respectively. The mouse genes encoding Lpin1 Lpin2 and Lpin3 mapped to chromosome 12 17 and 2 respectively. [provided by RefSeq Jul 2008]

Gene Symbol:   LPIN3
Gene Name:   lipin 3
Aliases:   LIPN3L, SMP2, dJ450M14.2, dJ450M14.3, dJ620E11.2
RefSeq:   NC_000020.10 NT_011362.10
Ensembl:   ENSG00000132793
Entrez:   64900
UniGene:   Hs.25897
Chromosome Mapping:   20q12

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