This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051706; exonic
This gene encodes a retina-specific guanylate cyclase which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain a single membrane spanning domain a kinase homology domain and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq Dec 2008]