This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0051549; exonic
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid lipopolysaccharide (LPS) on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI) the encoded protein binds LPS and interacts with the CD14 receptor probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins including BPI plasma cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP). Finally this gene is found on chromosome 20 immediately downstream of the BPI gene. [provided by RefSeq Jul 2008]