PrimePCR™ ddPCR™ Expression Probe Assay: MBD4, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051509; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5036154
Chromosome Location:   3:129151977-129152086question
Amplicon Length:   80

Gene Information

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2 MBD1 MBD2 MBD3 and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins with the exception of MBD3 is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI) a form of genomic instability associated with defective DNA mismatch repair and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq Jul 2008]

Gene Symbol:   MBD4
Gene Name:   methyl-CpG binding domain protein 4
Aliases:   MED1
RefSeq:   NC_000003.11 NG_023392.1 NT_005612.16
Ensembl:   ENSG00000129071
Entrez:   8930
UniGene:   Hs.35947
Chromosome Mapping:   3q21.3

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