PrimePCR™ ddPCR™ Expression Probe Assay: SMG7, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0050956; exonic

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5035210
Chromosome Location:   1:183485122-183486923question
Amplicon Length:   76

Gene Information

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists in part of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq Aug 2011]

Gene Symbol:   SMG7
Gene Name:   Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Aliases:   C1orf16, EST1C, FLJ23717, KIAA0250, SGA56M
RefSeq:   NC_000001.10 NG_007267.1 NT_004487.19
Ensembl:   ENSG00000116698
Entrez:   9887
UniGene:   Hs.591463
Chromosome Mapping:   1q25

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