PrimePCR™ ddPCR™ Expression Probe Assay: NR3C1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050768; exonic

 
Fluorophore:   HEX
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5034857
Chromosome Location:   5:142780165-142780312question
Amplicon Length:   118

Gene Information

This gene encodes glucocorticoid receptor which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm but upon ligand binding is transported into the nucleus. It is involved in inflammatory responses cellular proliferation and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described and shown to be functional displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq Feb 2011]

Gene Symbol:   NR3C1
Gene Name:   nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Aliases:   GCCR, GCR, GR, GRL
RefSeq:   NC_000005.9 NT_029289.11 NG_009062.1
Ensembl:   ENSG00000113580
Entrez:   2908
UniGene:   Hs.122926
Chromosome Mapping:   5q31.3

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