This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050701; exonic
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain approximately 400 amino acids in length and consisting of seven conserved motifs has been shown to possess phosphoinositide phosphatase activity. The yeast homolog Sac1p is involved in the regulation of various phosphoinositides and affects diverse cellular functions such as actin cytoskeleton organization Golgi function and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease type 4J. [provided by RefSeq Jul 2008]