PrimePCR™ ddPCR™ Expression Probe Assay: PSMC1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0050081; exonic

 
Fluorophore:   FAM
List Price:    $195.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033636
Chromosome Location:   14:90738678-90738796question
Amplicon Length:   89

Gene Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base which contains 6 ATPase subunits and 2 non-ATPase subunits and a lid which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome the immunoproteasome is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally this subunit interacts with ataxin-7 suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7 a progressive neurodegenerative disorder. [provided by RefSeq Jul 2008]

Gene Symbol:   PSMC1
Gene Name:   proteasome (prosome, macropain) 26S subunit, ATPase, 1
Aliases:   MGC24583, MGC8541, P26S4, S4, p56
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000100764
Entrez:   5700
UniGene:   Hs.356654
Chromosome Mapping:   14q32.11

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