PrimePCR™ ddPCR™ Expression Probe Assay: CMA1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049906; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033307
Chromosome Location:   14:24975701-24975798question
Amplicon Length:   68

Gene Information

This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix the regulation of submucosal gland secretion and the generation of vasoactive peptides. In the heart and blood vessels this protein rather than angiotensin converting enzyme is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension cardiac hypertrophy and heart failure. Thus this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq Jul 2008]

Gene Symbol:   CMA1
Gene Name:   chymase 1, mast cell
Aliases:   CYH, MCT1, MGC119890, MGC119891, chymase
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000092009
Entrez:   1215
UniGene:   Hs.135626
Chromosome Mapping:   14q11.2

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