PrimePCR™ ddPCR™ Expression Probe Assay: HSPG2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0039323; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5029897
Chromosome Location:   1:22222681-22222779question
Amplicon Length:   69

Gene Information

This gene encodes the perlecan protein which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin prolargin collagen type IV FGFBP1 FBLN2 FGF7 and Transthyretin etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g. FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1 Silverman-Handmaker type of dyssegmental dysplasia and Tardive dyskinesia.[provided by RefSeq Mar 2010]

Gene Symbol:   HSPG2
Gene Name:   heparan sulfate proteoglycan 2
RefSeq:   NC_000001.10 NG_016740.1 NT_004610.19
Ensembl:   ENSG00000142798
Entrez:   3339
UniGene:   Hs.562227
Chromosome Mapping:   1p36.1-p34

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