PrimePCR™ ddPCR™ Expression Probe Assay: BCL2A1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0039313; exonic

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5029882
Chromosome Location:   15:80263206-80263315question
Amplicon Length:   80

Gene Information

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators and is up-regulated by different extracellular signals such as granulocyte-macrophage colony-stimulating factor (GM-CSF) CD40 phorbol ester and inflammatory cytokine TNF and IL-1 which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   BCL2A1
Gene Name:   BCL2-related protein A1
Aliases:   ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1
RefSeq:   NC_000015.9 NT_010194.17
Ensembl:   ENSG00000140379
Entrez:   597
UniGene:   Hs.227817
Chromosome Mapping:   15q24.3

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