PrimePCR™ ddPCR™ Expression Probe Assay: COCH, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0039091; exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5029617
Chromosome Location:   14:31349793-31349924question
Amplicon Length:   102

Gene Information

The protein encoded by this gene is highly conserved in human mouse and chicken showing 94% and 79% amino acid identity of human to mouse and chicken sequences respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits consistent with mucopolysaccharide ground substance in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq Oct 2008]

Gene Symbol:   COCH
Gene Name:   coagulation factor C homolog, cochlin (Limulus polyphemus)
Aliases:   COCH-5B2, COCH5B2, DFNA9
RefSeq:   NC_000014.8 NT_026437.12 NG_008211.2
Ensembl:   ENSG00000100473
Entrez:   1690
UniGene:   Hs.21016
Chromosome Mapping:   14q12-q13

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