PrimePCR™ ddPCR™ Expression Probe Assay: ALS2, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0039009; exonic

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5029533
Chromosome Location:   2:202626474-202631979question
Amplicon Length:   65

Gene Information

The protein encoded by this gene contains an ATS1/RCC1-like domain a RhoGEF domain and a vacuolar protein sorting 9 (VPS9) domain all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Oct 2008]

Gene Symbol:   ALS2
Gene Name:   amyotrophic lateral sclerosis 2 (juvenile)
Aliases:   ALS2CR6, ALSJ, FLJ31851, IAHSP, KIAA1563, MGC87187, PLSJ
RefSeq:   NC_000002.11 NT_005403.17 NG_008775.1 NG_012654.1
Ensembl:   ENSG00000003393
Entrez:   57679
UniGene:   Hs.471096
Chromosome Mapping:   2q33.1

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