PrimePCR™ ddPCR™ Expression Probe Assay: TIRAP, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0035601; Exonic

 
Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5029363
Chromosome Location:   11:126159560-126159700question
Amplicon Length:   111

Gene Information

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs) which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B MAPK1 MAPK3 and JNK which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however not all variants have been fully described. [provided by RefSeq Jul 2008]

Gene Symbol:   TIRAP
Gene Name:   toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases:   FLJ42305, Mal, wyatt
RefSeq:   NC_000011.9 NG_011523.1 NT_033899.8
Ensembl:   ENSG00000150455
Entrez:   114609
UniGene:   Hs.537126
Chromosome Mapping:   11q24.2

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