This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0032553; Exonic
Presenilins which are components of the gamma-secretase protein complex are required for intramembranous processing of some type I transmembrane proteins such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling and for the activity and accumulation of gamma-secretase. [provided by RefSeq Jul 2008]