PrimePCR™ ddPCR™ Expression Probe Assay: APH1A, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0025677; Exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5027747
Chromosome Location:   1:150239772-150239873question
Amplicon Length:   72

Gene Information

This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product or the paralogous anterior pharynx defective 1 homolog B (APH1B) along with the presenilin nicastrin and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq Aug 2011]

Gene Symbol:   APH1A
Gene Name:   anterior pharynx defective 1 homolog A (C. elegans)
Aliases:   6530402N02Rik, APH-1, APH-1A, CGI-78
RefSeq:   NC_000001.10 NT_004487.19
Ensembl:   ENSG00000117362
Entrez:   51107
UniGene:   Hs.108408
Chromosome Mapping:   1p36.13-q31.3

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