PrimePCR™ ddPCR™ Expression Probe Assay: NOD1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0025266; Exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5027329
Chromosome Location:   7:30496405-30496609question
Amplicon Length:   175

Gene Information

This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD) a centrally located nucleotide-binding domain (NBD) and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling LRRs participate in protein-protein interactions and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described but the full-length nature of these variants has not been determined. [provided by RefSeq Oct 2009]

Gene Symbol:   NOD1
Gene Name:   nucleotide-binding oligomerization domain containing 1
Aliases:   CARD4, CLR7.1, NLRC1
RefSeq:   NC_000007.13 NG_013025.1 NT_007819.17
Ensembl:   ENSG00000106100
Entrez:   10392
UniGene:   Hs.405153
Chromosome Mapping:   7p15-p14

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