Process-scale chromatography columns, liquid handling systems, and accessories are designed for industrial scale purifications and are solvent resistant. All are fully supported for regulatory submissions.
Bio-Rad InPlace process-scale chromatography columns are designed for industrial applications and allow contained filling, packing, unpacking, and cleaning in place for safe and hygienic column operation. To learn more about Bio-Rad InPlace columns, click on the video.
Bio-Rad's process chromatography skid 00 is the industry's first compact skid designed for small-scale GMP biopharmaceutical manufacturing. The skid can be interchanged with multiple columns ranging in diameter from 70 to 300 mm with flow rates from 5 to 120 L/hr. To learn more click the video.
Custom Design Solutions The ability to design and manufacture customized process chromatography equipment is one of Bio-Rad's significant strengths. Individual projects are marked by intensive interaction between the customer and Bio-Rad designers, engineers, and quality assurance personnel. Considerable experience in separation technology means that new designs can be produced quickly for specific applications.
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A Warm Welcome Bio-Rad Laboratories welcomes you to our pilot-scale development laboratory for process chromatography. Located at Bio-Rad corporate headquarters in Hercules, California, on the southeastern shore of the San Pablo Bay, the laboratory offers access to state-of-the-art chromatography equipment and media and to the expertise of our team of separations scientists and engineers. Working with laboratory staff, you will have the opportunity to operate chromatography hardware, optimize your packing procedures, and review optimal solutions for your manufacturing processes.
Bio-Rad EasyPack columns are open columns with an adjustable bed-height adaptor and fixed bottom endpieces. Their sanitary design ensures hygienic performance and thorough cleaning. To learn more, click on the video.
The Bio-Rad media transfer device is a self-contained movable unit designed to transfer chromatography media between a tank and the column and to deliver cleaning solutions to Bio-Rad InPlace columns for sanitization. To learn more click on the video.
The Bio-Rad MainFrame Lifting accessory enables hoist-free operation of chromatography columns. To learn more click on the video.
Bio-Rad InPlace process-scale chromatography columns are designed for industrial applications with contained filling, packing, unpacking, and cleaning for safe and hygienic column operation. To learn more about Bio-Rad InPlace columns, click on the video.
Introduction Ceramic hydroxyapatite requires special consideration during process-scale chromatography packing primarily due to its high specific gravity and rapid settling rate. Ceramic hydroxyapatite media have a bulk density of 0.63 g/ml and a free settling velocity of 35–125 cm/hr for 40 µm and 125–275 cm/hr for 80 µm. Additionally, ceramic hydroxyapatite media are sensitive to mechanical shear, which can fracture the particles and produce fines.
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