Target Discovery: Identification and Validation

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en-us NU4ETNE8Z Target Discovery Target Discovery: Identification and Validation /webroot/web/html/lsr/solutions/applications/drug_discovery <script type="text/javascript"><!-- $(document).ready(function(){ $('.pagecontent2').hide(); $(".content-show").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:0}, 500); }); $(".content-hide").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:100}, 800); }); }); // --></script> <div class="ddflow-container"> <ul class="ddflow"> <li class="ddflow-selected">Target <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-target-discovery.jpg" alt="Target Discovery" /></div> </li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/lead-discovery-screening-optimization">Lead <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-lead-discovery.jpg" alt="Lead Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/preclinical-research">Preclinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-preclinical-research.jpg" alt="Preclinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/clinical-research">Clinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-clincal-research.jpg" alt="Clinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/process-development-scale">Process <br />Development<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-process-development.jpg" alt="Process Development" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/pharmaceutical-manufacturing-release-testing">Manufacturing<br />and Testing<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-manufacturing.jpg" alt="Pharmaceutical Manufacturing and Release Testing" /></div> </a></li> </ul> </div> &nbsp; <p>The first stage of drug development is target discovery, also known as target identification and validation, the process of identifying a potential target for a therapeutic drug for a particular disease or condition that does not have a treatment or for which existing therapeutic agents are lacking in some way. Thus, targets may be known, putative, or novel. Proteins are the most common targets and include enzymes, cell signaling receptors, structural proteins, and regulatory factors such as protein kinases. Other targets that are increasingly being investigated include nucleic acids such as mRNA, lipids, and carbohydrates. <span class="content-show" style="display:inline">Show more</span></p> <p class="content-more">There are two main approaches to drug discovery, phenotype-based and target-based. Recently, there has been a resurgence in phenotype-based screening, which is monitoring changes cells in cells, tissues, or organisms. This type of screening has the ability to identify molecules and pathways that were previously not known to be involved in a disease. In target-based screening, each candidate target is validated by numerous experimental methods including modulation of the target to demonstrate that it is directly or indirectly involved in the disease or condition of interest.</p> <p class="content-more">In choosing a target, the probability of it being druggable must also be considered; that is, a drug must be able to bind the target and affect its function in a desirable way. Therefore, the target must be accessible to putative therapeutic agents, and the interaction should produce a measurable biological response. There are a wide range of experimental technologies used for validation, with the validation protocols varying depending on the function and characteristics of the target. <span class="content-hide">Show less</span></p> <p>&nbsp;</p> Feature Articles <table border="0"> <tbody> <tr valign="top"> <td width="50%" height="100"> <p><a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank"><img style="float:left; margin-right:10px" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/6877-thumb.jpg" alt="" width="57" height="72" /></a><strong>Bio-Rad's Drug Discovery and Development Workflow Solutions</strong><br />Learn how Bio-Rad's products align with your drug discovery and development workflows &nbsp;<a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank">Download</a></p> </td> <td width="50%"> <p><a href="/webroot/web/pdf/lsr/literature/Bulletin_6634.pdf" target="_blank"><img style="float:left; margin-right:10px" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/6634-thumb.jpg" alt="" width="57" height="72" /></a>A Fast Semi-Automated Quantitative PCR Method for Monitoring Differential Gene Expression for Drug Target Discovery&nbsp;<a href="/webroot/web/pdf/lsr/literature/Bulletin_6634.pdf" target="_blank">Download</a></p> </td> </tr> </tbody> </table> <br /> Solutions for Target Discovery: Identification and Validation <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/gene-expression.jpg" alt="Gene Expression" /></p> </td> <td align="left" valign="top"> <h4>Gene Expression</h4> <p style="margin-top:-7px">Analyze gene expression, determine copy number variation (CNV), and initiate early biomarker discovery across a variety of biological samples with our range of validated PCR, qPCR, and Droplet Digital&trade; PCR instruments and reagents.</p> <p><span class="hidden US-only CA-only AT-only BE-only CZ-only DK-only FI-only FR-only DE-only HU-only IT-only LU-only NO-only PL-only PT-only ES-only NL-only SE-only CH-only UK-only AU-only NZ-only SG-only CN-only TW-only HK-only MO-only TH-only ZA-only IN-only IL-only KR-only JP-only">Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.</span></p> <p><a href="/en-us/category/digital-pcr">Droplet Digital PCR Systems</a><br /> <a href="/en-us/product/cfx-automation-system-ii">Real-Time PCR Automation</a><br /> <span class="hidden US-only CA-only AT-only BE-only DK-only FI-only FR-only DE-only IT-only LU-only NO-only PT-only ES-only NL-only SE-only CH-only UK-only AU-only NZ-only SG-only KR-only JP-only"><a href="/en-us/product/pcr-primers-probes-panels"> PCR Primers, Probes, and Assays</a> <br /></span><a href="/en-us/category/pcr-instrument-validation-tools-services">PCR Instrument Validation Tools and Services</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/protein-expression.jpg" alt="Protein Expression" /></p> </td> <td align="left" valign="top"> <h4>Protein Expression</h4> <p style="margin-top:-7px">Utilize multiplex immunoassays and our complete western blotting solutions, including gels, imagers, and validated antibodies, in your drug discovery process. Fast, reproducible assessment of proteins with built-in controls and validation steps for protein quantitation streamlines proteomics analysis and monitoring of protein expression levels.</p> <p><a href="/en-us/product/bio-plex-pro-human-cancer-biomarker-assays">Multiplex Cancer Immunoassays </a><br /> <a href="/en-us/product/human-inflammation-assays">Multiplex Human Inflammation Immunoassays </a><br /> <a href="/en-us/category/western-blotting">Western Blotting Reagents and Equipment </a><br /> <a href="/en-us/category/gel-imaging-systems">Stain-Free Gel and Western Blot Imaging Systems</a><br /> <a href="/en-us/product/precisionab-validated-western-blotting-antibodies">Validated Western Blotting Antibodies </a><br /> <a href="/en-us/category/2-d-electrophoresis">2-D Electrophoresis Systems</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-analysis.jpg" alt="Cell Analysis" /></p> </td> <td align="left" valign="top"> <h4>Cell Analysis</h4> <p style="margin-top:-7px">Use our comprehensive selection of equipment systems, antibodies, assays, and reagents for isolation, characterization, imaging and analysis of both individual cells and populations. Evaluate your studies with our multi-parameter, expandable, easy to use flow cytometers, automated cell sorters and counters, and cell imagers.</p> <p><a href="/en-us/category/cell-imaging">Cell Imaging</a><br /><a href="/en-us/category/cell-counting">Cell Counting</a><br /> <a href="/en-us/category/flow-cytometry">Cell Sorting and Flow Cytometry</a><br /> <a href="/en-us/product/flow-cytometry-antibodies">Antibodies for Flow Cytometry</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/antibodies.jpg" alt="Antibodies" /></p> </td> <td align="left" valign="top"> <h4>Antibodies</h4> <p style="margin-top:-7px">Discover an extensive range of antibodies for applications such as flow cytometry, immunohistochemistry (IHC), western blotting, and ELISA to support your cell-based and proteomics target discovery. Custom services are available to meet your specific target identification and characterization needs</p> <p><a class="new-target-image" href="https://www.abdserotec.com/antibody-applications.html" target="_blank">Antibodies by Application </a><br /> <a class="new-target-image" href="https://www.abdserotec.com/antibodies-by-target-species.html" target="_blank">Antibodies by Target Species </a><br /> <a class="new-target-image" href="https://www.abdserotec.com/cell-biology-antibodies.html" target="_blank">Cell Signaling Antibodies</a><br /> <a class="new-target-image" href="https://www.abdserotec.com/custom-antibody-services.html" target="_blank">HuCAL<sup>&reg;</sup> Custom Antibody Services </a></p> </td> </tr> </tbody> </table> Additional Methodologies and Research within Drug Discovery and Development <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biomarker-discovery.jpg" alt="Biomarker Discovery" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biomarker-discovery"><strong>Biomarker Discovery</strong></a><br />The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate&rsquo;s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to physiological parameters such as blood pressure. Biomarkers may be detected in a specific location or tissue or in plasma and other bodily fluids.<a href="/en-us/applications-technologies/biomarker-discovery"><strong><br /></strong></a></p> </td> </tr> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biochemical-and-cellular-assays.jpg" alt="Biochemical and Cellular Assays" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong>Biochemical and Cellular Assays</strong></a><br />Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.<a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong><br /></strong></a></p> </td> </tr> </tbody> </table> Karen Moss Target Discovery: Identification and Validation Learn about target discovery in drug discovery & development. drug discovery, discovery, drug development, development, pharma, pharmaceutical, target discovery 10/06/15 01:51 PM 10/06/25 02:00 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Applications/Drug_Discovery N 0 Drug Discovery and Development /en-us/applications-technologies/applications-technologies/target-discovery-identification-validation?ID=NU4EE515
 

The first stage of drug development is target discovery, also known as target identification and validation, the process of identifying a potential target for a therapeutic drug for a particular disease or condition that does not have a treatment or for which existing therapeutic agents are lacking in some way. Thus, targets may be known, putative, or novel. Proteins are the most common targets and include enzymes, cell signaling receptors, structural proteins, and regulatory factors such as protein kinases. Other targets that are increasingly being investigated include nucleic acids such as mRNA, lipids, and carbohydrates. Show more

There are two main approaches to drug discovery, phenotype-based and target-based. Recently, there has been a resurgence in phenotype-based screening, which is monitoring changes cells in cells, tissues, or organisms. This type of screening has the ability to identify molecules and pathways that were previously not known to be involved in a disease. In target-based screening, each candidate target is validated by numerous experimental methods including modulation of the target to demonstrate that it is directly or indirectly involved in the disease or condition of interest.

In choosing a target, the probability of it being druggable must also be considered; that is, a drug must be able to bind the target and affect its function in a desirable way. Therefore, the target must be accessible to putative therapeutic agents, and the interaction should produce a measurable biological response. There are a wide range of experimental technologies used for validation, with the validation protocols varying depending on the function and characteristics of the target. Show less

 

 

Feature Articles

Bio-Rad's Drug Discovery and Development Workflow Solutions
Learn how Bio-Rad's products align with your drug discovery and development workflows  Download

A Fast Semi-Automated Quantitative PCR Method for Monitoring Differential Gene Expression for Drug Target Discovery Download


 

Solutions for Target Discovery: Identification and Validation

Gene Expression

Gene Expression

Analyze gene expression, determine copy number variation (CNV), and initiate early biomarker discovery across a variety of biological samples with our range of validated PCR, qPCR, and Droplet Digital™ PCR instruments and reagents.

Droplet Digital PCR Systems
Real-Time PCR Automation
PCR Instrument Validation Tools and Services

Protein Expression

Protein Expression

Utilize multiplex immunoassays and our complete western blotting solutions, including gels, imagers, and validated antibodies, in your drug discovery process. Fast, reproducible assessment of proteins with built-in controls and validation steps for protein quantitation streamlines proteomics analysis and monitoring of protein expression levels.

Multiplex Cancer Immunoassays
Multiplex Human Inflammation Immunoassays
Western Blotting Reagents and Equipment
Stain-Free Gel and Western Blot Imaging Systems
Validated Western Blotting Antibodies
2-D Electrophoresis Systems

Cell Analysis

Cell Analysis

Use our comprehensive selection of equipment systems, antibodies, assays, and reagents for isolation, characterization, imaging and analysis of both individual cells and populations. Evaluate your studies with our multi-parameter, expandable, easy to use flow cytometers, automated cell sorters and counters, and cell imagers.

Cell Imaging
Cell Counting
Cell Sorting and Flow Cytometry
Antibodies for Flow Cytometry

Antibodies

Antibodies

Discover an extensive range of antibodies for applications such as flow cytometry, immunohistochemistry (IHC), western blotting, and ELISA to support your cell-based and proteomics target discovery. Custom services are available to meet your specific target identification and characterization needs

Antibodies by Application
Antibodies by Target Species
Cell Signaling Antibodies
HuCAL® Custom Antibody Services

 

Additional Methodologies and Research within Drug Discovery and Development

Biomarker Discovery

Biomarker Discovery
The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate’s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to physiological parameters such as blood pressure. Biomarkers may be detected in a specific location or tissue or in plasma and other bodily fluids.

Biochemical and Cellular Assays

Biochemical and Cellular Assays
Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.

 
NU4ETNE8Z [x-forwarded-proto] = [http] [x-forwarded-port] = [80] [x-forwarded-for] = [54.158.199.217, 10.232.2.159] [accept] = [text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8] [seourl] = [/en-us/applications-technologies/target-discovery-identification-validation] [x-amzn-trace-id] = [Root=1-5ba4d120-0b156d5c4a7442004679c1be] [x-forwarded-server] = [lsds-prod-s.br.aws-livesite.io] [x-forwarded-host] = [www.bio-rad.com] [x-query-string] = [ID=NU4ETNE8Z] [host] = [10.232.17.28:1776] [x-request-uri] = [/en-us/applications-technologies/target-discovery-identification-validation] [connection] = [Keep-Alive] [accept-encoding] = [gzip] [user-agent] = [CCBot/2.0 (https://commoncrawl.org/faq/)] AppTech/AppTechDetails pageStyleKey internet/solutions_sub applications-technologies/target-discovery-identification-validation LSR NU4ETNE8Z Target Discovery Target Discovery: Identification and Validation /webroot/web/html/lsr/solutions/applications/drug_discovery <script type="text/javascript"><!-- $(document).ready(function(){ $('.pagecontent2').hide(); $(".content-show").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:0}, 500); }); $(".content-hide").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:100}, 800); }); }); // --></script> <div class="ddflow-container"> <ul class="ddflow"> <li class="ddflow-selected">Target <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-target-discovery.jpg" alt="Target Discovery" /></div> </li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/lead-discovery-screening-optimization">Lead <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-lead-discovery.jpg" alt="Lead Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/preclinical-research">Preclinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-preclinical-research.jpg" alt="Preclinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/clinical-research">Clinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-clincal-research.jpg" alt="Clinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/process-development-scale">Process <br />Development<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-process-development.jpg" alt="Process Development" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li><a href="/en-us/applications-technologies/pharmaceutical-manufacturing-release-testing">Manufacturing<br />and Testing<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-manufacturing.jpg" alt="Pharmaceutical Manufacturing and Release Testing" /></div> </a></li> </ul> </div> &nbsp; <p>The first stage of drug development is target discovery, also known as target identification and validation, the process of identifying a potential target for a therapeutic drug for a particular disease or condition that does not have a treatment or for which existing therapeutic agents are lacking in some way. Thus, targets may be known, putative, or novel. Proteins are the most common targets and include enzymes, cell signaling receptors, structural proteins, and regulatory factors such as protein kinases. Other targets that are increasingly being investigated include nucleic acids such as mRNA, lipids, and carbohydrates. <span class="content-show" style="display:inline">Show more</span></p> <p class="content-more">There are two main approaches to drug discovery, phenotype-based and target-based. Recently, there has been a resurgence in phenotype-based screening, which is monitoring changes cells in cells, tissues, or organisms. This type of screening has the ability to identify molecules and pathways that were previously not known to be involved in a disease. In target-based screening, each candidate target is validated by numerous experimental methods including modulation of the target to demonstrate that it is directly or indirectly involved in the disease or condition of interest.</p> <p class="content-more">In choosing a target, the probability of it being druggable must also be considered; that is, a drug must be able to bind the target and affect its function in a desirable way. Therefore, the target must be accessible to putative therapeutic agents, and the interaction should produce a measurable biological response. There are a wide range of experimental technologies used for validation, with the validation protocols varying depending on the function and characteristics of the target. <span class="content-hide">Show less</span></p> <p>&nbsp;</p> Feature Articles <table border="0"> <tbody> <tr valign="top"> <td width="50%" height="100"> <p><a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank"><img style="float:left; margin-right:10px" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/6877-thumb.jpg" alt="" width="57" height="72" /></a><strong>Bio-Rad's Drug Discovery and Development Workflow Solutions</strong><br />Learn how Bio-Rad's products align with your drug discovery and development workflows &nbsp;<a href="/webroot/web/pdf/lsr/literature/Bulletin_6877.pdf" target="_blank">Download</a></p> </td> <td width="50%"> <p><a href="/webroot/web/pdf/lsr/literature/Bulletin_6634.pdf" target="_blank"><img style="float:left; margin-right:10px" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/6634-thumb.jpg" alt="" width="57" height="72" /></a>A Fast Semi-Automated Quantitative PCR Method for Monitoring Differential Gene Expression for Drug Target Discovery&nbsp;<a href="/webroot/web/pdf/lsr/literature/Bulletin_6634.pdf" target="_blank">Download</a></p> </td> </tr> </tbody> </table> <br /> Solutions for Target Discovery: Identification and Validation <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/gene-expression.jpg" alt="Gene Expression" /></p> </td> <td align="left" valign="top"> <h4>Gene Expression</h4> <p style="margin-top:-7px">Analyze gene expression, determine copy number variation (CNV), and initiate early biomarker discovery across a variety of biological samples with our range of validated PCR, qPCR, and Droplet Digital&trade; PCR instruments and reagents.</p> <p><span class="hidden US-only CA-only AT-only BE-only CZ-only DK-only FI-only FR-only DE-only HU-only IT-only LU-only NO-only PL-only PT-only ES-only NL-only SE-only CH-only UK-only AU-only NZ-only SG-only CN-only TW-only HK-only MO-only TH-only ZA-only IN-only IL-only KR-only JP-only">Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.</span></p> <p><a href="/en-us/category/digital-pcr">Droplet Digital PCR Systems</a><br /> <a href="/en-us/product/cfx-automation-system-ii">Real-Time PCR Automation</a><br /> <span class="hidden US-only CA-only AT-only BE-only DK-only FI-only FR-only DE-only IT-only LU-only NO-only PT-only ES-only NL-only SE-only CH-only UK-only AU-only NZ-only SG-only KR-only JP-only"><a href="/en-us/product/pcr-primers-probes-panels"> PCR Primers, Probes, and Assays</a> <br /></span><a href="/en-us/category/pcr-instrument-validation-tools-services">PCR Instrument Validation Tools and Services</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/protein-expression.jpg" alt="Protein Expression" /></p> </td> <td align="left" valign="top"> <h4>Protein Expression</h4> <p style="margin-top:-7px">Utilize multiplex immunoassays and our complete western blotting solutions, including gels, imagers, and validated antibodies, in your drug discovery process. Fast, reproducible assessment of proteins with built-in controls and validation steps for protein quantitation streamlines proteomics analysis and monitoring of protein expression levels.</p> <p><a href="/en-us/product/bio-plex-pro-human-cancer-biomarker-assays">Multiplex Cancer Immunoassays </a><br /> <a href="/en-us/product/human-inflammation-assays">Multiplex Human Inflammation Immunoassays </a><br /> <a href="/en-us/category/western-blotting">Western Blotting Reagents and Equipment </a><br /> <a href="/en-us/category/gel-imaging-systems">Stain-Free Gel and Western Blot Imaging Systems</a><br /> <a href="/en-us/product/precisionab-validated-western-blotting-antibodies">Validated Western Blotting Antibodies </a><br /> <a href="/en-us/category/2-d-electrophoresis">2-D Electrophoresis Systems</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-analysis.jpg" alt="Cell Analysis" /></p> </td> <td align="left" valign="top"> <h4>Cell Analysis</h4> <p style="margin-top:-7px">Use our comprehensive selection of equipment systems, antibodies, assays, and reagents for isolation, characterization, imaging and analysis of both individual cells and populations. Evaluate your studies with our multi-parameter, expandable, easy to use flow cytometers, automated cell sorters and counters, and cell imagers.</p> <p><a href="/en-us/category/cell-imaging">Cell Imaging</a><br /><a href="/en-us/category/cell-counting">Cell Counting</a><br /> <a href="/en-us/category/flow-cytometry">Cell Sorting and Flow Cytometry</a><br /> <a href="/en-us/product/flow-cytometry-antibodies">Antibodies for Flow Cytometry</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p style="margin-top:0px"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/antibodies.jpg" alt="Antibodies" /></p> </td> <td align="left" valign="top"> <h4>Antibodies</h4> <p style="margin-top:-7px">Discover an extensive range of antibodies for applications such as flow cytometry, immunohistochemistry (IHC), western blotting, and ELISA to support your cell-based and proteomics target discovery. Custom services are available to meet your specific target identification and characterization needs</p> <p><a class="new-target-image" href="https://www.abdserotec.com/antibody-applications.html" target="_blank">Antibodies by Application </a><br /> <a class="new-target-image" href="https://www.abdserotec.com/antibodies-by-target-species.html" target="_blank">Antibodies by Target Species </a><br /> <a class="new-target-image" href="https://www.abdserotec.com/cell-biology-antibodies.html" target="_blank">Cell Signaling Antibodies</a><br /> <a class="new-target-image" href="https://www.abdserotec.com/custom-antibody-services.html" target="_blank">HuCAL<sup>&reg;</sup> Custom Antibody Services </a></p> </td> </tr> </tbody> </table> Additional Methodologies and Research within Drug Discovery and Development <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biomarker-discovery.jpg" alt="Biomarker Discovery" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biomarker-discovery"><strong>Biomarker Discovery</strong></a><br />The use of biomarkers across drug discovery and development and into the clinic is key to enabling close monitoring of a drug candidate&rsquo;s effects. Biomarkers can range from specific molecules such as a protein, a gene sequence, or expressed RNA to physiological parameters such as blood pressure. Biomarkers may be detected in a specific location or tissue or in plasma and other bodily fluids.<a href="/en-us/applications-technologies/biomarker-discovery"><strong><br /></strong></a></p> </td> </tr> <tr> <td align="left" valign="top"> <p><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/biochemical-and-cellular-assays.jpg" alt="Biochemical and Cellular Assays" /></p> </td> <td align="left" valign="top"> <p><a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong>Biochemical and Cellular Assays</strong></a><br />Biochemical and cellular pharmacology teams develop and validate assays to support research across drug discovery and development. These assays range from discovery approaches with high sample throughput to high-content analysis to gain an understanding of biological response both in vitro and in vivo.<a href="/en-us/applications-technologies/biochemical-cellular-assays"><strong><br /></strong></a></p> </td> </tr> </tbody> </table> Karen Moss Target Discovery: Identification and Validation Learn about target discovery in drug discovery & development. drug discovery, discovery, drug development, development, pharma, pharmaceutical, target discovery 10/06/15 01:51 PM 10/06/25 02:00 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Applications/Drug_Discovery N 0
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