Biomarker Discovery and Validation

Print

Overview

en-us NU4F7VMNI Biomarker Discovery Biomarker Discovery and Validation /webroot/web/html/lsr/solutions/applications/drug_discovery <script type="text/javascript">// <![CDATA[ $(document).ready(function(){ $('.pagecontent2').hide(); $(".content-show").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:0}, 500); }); $(".content-hide").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:100}, 800); }); }); // ]]></script> <div class="ddflow-container"> <ul class="ddflow"> <li class="ddflow-on"><a href="/en-us/applications-technologies/target-discovery-identification-validation">Target <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-target-discovery.jpg" alt="Target Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/lead-discovery-screening-optimization">Lead <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-lead-discovery.jpg" alt="Lead Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/preclinical-research">Preclinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-preclinical-research.jpg" alt="Preclinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/clinical-research">Clinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-clincal-research.jpg" alt="Clinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/process-development-scale">Process <br />Development<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-process-development.jpg" alt="Process Development" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li>&nbsp;<br /><a href="/en-us/applications-technologies/pharmaceutical-manufacturing-release-testing">Manufacturing<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-manufacturing.jpg" alt="Pharmaceutical Manufacturing and Release Testing" /></div> </a></li> </ul> </div> <div class="ddflow-othr-container ddflow-othr-container-biomarker"> <div class="ddflow-othr-biomarker"> <div class="ddflow-othr-main ddflow-biomarker">Biomarker Discovery and Validation</div> </div> </div> <br style="clear: both;" />&nbsp; <p><strong>Biomarker Discovery</strong><br />Biomarkers provide vital information regarding safety and efficacy during drug discovery and development. They are loosely defined as diagnostic, prognostic, or predictive and can be used to select patients for clinical trials or monitor patient response and treatment efficacy. In addition, after regulatory approval, biomarkers can be used to identify patient populations that would benefit from a particular therapy along with continuing to monitor the treatment&rsquo;s efficacy. <span class="content-show"> Show more</span></p> <p class="content-more">Biomarkers are used in research to design and develop more effective therapeutics, to assist in guiding decisions about which candidates to develop further, as surrogate markers for the selection of patients, and as endpoints for both benefits and risks. There are a wide range of types of biomarkers that can be monitored, such as predictive, prognostic, pharmacodynamic, safety, and efficacy markers. One class of biomarkers that is actively being researched is safety biomarkers. These markers are being developed to help determine which drug candidates are most likely to be safely tolerated in humans.</p> <p class="content-more"><strong>From Discovery to Validation</strong><br /> Biomarkers range from specific molecules such as a protein, gene sequence, or expressed RNA to physiological parameters such as blood pressure or body temperature. They may be expressed in a specific location or tissue or found in serum, plasma, and other bodily fluids. Because of this diversity, most successful biomarker programs have a broad reach and investigate cellular, proteomic, and genetic sources in order to find the most valuable biomarkers.</p> <p class="content-more">Validation of biomarkers requires that their levels change in response to a disease, condition, or other parameter in a consistent and statistically significant manner. Identification and characterization of biomarkers can reduce the number of candidate drugs that fail clinical trials, aid in the discovery of more effective therapeutics, and provide methods for monitoring animals in preclinical research and evaluating the response of human participants in clinical trials.</p> <p class="content-more"><strong>Genomic Biomarkers</strong><br /> Both gene expression and the presence of specific genetic sequences are used as biomarkers for many diseases including cancer. Treatments can even be tailored to an individual patient based on these genomic biomarkers. Typically, large-scale gene expression studies are conducted to identify genes that are up- or down-regulated in a particular indication or disease. These studies rely on the ability of the researchers to design exploratory and confirmatory panels as well as on powerful software tools to analyze resulting data and identify potential biomarkers.</p> <p class="content-more"><strong>Proteomic Biomarkers</strong><br /> Interrogating biological samples to identify proteomic profiles gives rise to a plethora of potential biomarkers. Proteins are vital, functional parts of living organisms and as such reflect what is happening in that organism. Monitoring the post-translational state of proteins of interest can yield important biomarkers and indicate tumor progression.</p> <p class="content-more"><strong>Cellular Biomarkers</strong><br /> The ability to uncover novel and rare cell types through multiparameter analysis allows researchers to characterize cell populations in greater detail and identify subpopulations that serve as markers for disease. Simple and reliable isolation of these cells for downstream assays further supports the cellular biomarker workflow by providing pure populations for genomic and proteomic analysis. <span class="content-hide">Show less</span></p> &nbsp; <p><a href="javascript:openAjaxOverlay(&quot;/webroot/web/html/lsr/solutions/applications/drug_discovery/ov-cell-sorting-drug-discovery-development-video.html&quot;);"><img style="float: left; margin-right: 10px;" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-sorting-for-drug-discovery-development-video.jpg" alt="Cell Sorting for Drug Discovery" width="79" height="45" /><strong>Featured Video</strong></a><br />Automated, Affordable Cell Sorting for Drug Discovery &amp; Development with the S3e&trade; Cell Sorter</p> <p>&nbsp;</p> Solutions for Biomarker Discovery <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/gene-expression.jpg" alt="Gene Expression" /></p> </td> <td align="left" valign="top"> <h4>Gene Expression</h4> <p style="margin-top: -7px;">Select from a range of validated PCR, qPCR, and digital PCR instruments to incorporate into your biomarker research. Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.</p> <p>CFX Real-Time PCR Detection Systems along with predesigned or custom-built or predesigned PrimePCR&trade; Panels for pathway or disease state targets allow you to measure multiple genes from multiple samples at once sourced from liquid biopsy, tissue, or cell based materials. Coupled with the CFX Automation System II, up to 48 plates can be read unattended. If increased sensitivity is required, such as for the detection and quantification of CTCs and rare cancer mutations, the QX200 Droplet Digital PCR (ddPCR&trade;) System is an ideal choice, as it allows detection of rare, low-abundance genetic biomarkers. Both systems are provided with IQ/OQ workflows and tools that enable 21 CFR Part 11 compliance.</p> <p><a href="/en-us/category/real-time-pcr-detection-systems">Real-Time PCR Detection Systems</a><br /><a href="/en-us/category/digital-pcr">Droplet Digital&trade; PCR Systems</a><br /> <a href="/en-us/product/residual-dna-quantification-supermixes">ddPCR&trade; Supermixes for Residual DNA Quantification</a></p> <div id="pcrPrimersprobesassaysLink" style="margin: -10px 0 -0px 0;"> <script type="text/javascript">// <![CDATA[ $('#pcrPrimersprobesassaysLink').load('/webroot/web/html/lsr/products/amplification_pcr/pcr-primers-probes-assays-link.html'); // ]]></script> </div> <a style="font-size: 12px;" href="/en-us/category/pcr-instrument-validation-tools-services">PCR Instrument Validation Tools and Services</a> <p>&nbsp;</p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/protein-expression-quantitation-analysis.jpg" alt="Protein Expression, Quantitation, and Analysis" /></p> </td> <td align="left" valign="top"> <h4>Protein Expression, Quantitation, and Analysis</h4> <p style="margin-top: -7px;">Analyze the expression of biomarkers in complex backgrounds with multiplex immunoassays, 1-D and 2-D electrophoresis, and western blotting.</p> <p>The V3 Western Workflow&trade; is a validated and streamlined workflow suite that allows faster quantitation of protein expression with more accuracy than other western blotting systems. By incorporating the ChemiDoc&trade; MP Imaging System, this workflow allows simultaneous analysis of up to three proteins via multiplex fluorescent western blotting. Bio-Plex Multiplex Immunoassay Systems and Assays allow analysis of large numbers of biomarkers in a single experiment. Predesigned panels for a given indication remove the guesswork from your search, while custom assays allow you to design panels for your unique markers as your biomarker program progresses.</p> <p><a href="/en-us/category/cell-signaling-assays">Multiplex Cell Signaling Immunoassays</a><br /> <a href="/en-us/product/bio-plex-pro-human-cancer-biomarker-assays">Multiplex Cancer Biomarker Immunoassays </a><br /> <a href="/en-us/category/kidney-toxicity-assays">Multiplex Kidney Toxicity Immunoassays </a><br /> <a href="/en-us/bio-plex-assay-builder">Custom Multiplex Immunoassays </a><br /> <a href="/en-us/category/2-d-electrophoresis">2-D Electrophoresis Systems</a><br /> <a href="/en-us/product/v3-western-workflow">V3 Western Workflow</a><br /> <a href="/en-us/category/gel-imaging-systems">Stain-Free Gel and Western Blot Imaging Systems</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-analysis.jpg" alt="Cell Analysis" /></p> </td> <td align="left" valign="top"> <h4>Cell Analysis</h4> <p style="margin-top: -7px;">Bio-Rad offers equipment and reagents for cell-based biomarker evaluation and measurement.</p> <p>Our comprehensive and easy-to-use suite of cell analysis products includes the ZE5&trade; Cell Analyzer, the S3e&trade; Cell Sorter, and the ZOE&trade; Fluorescent Cell Imager, and includes a wide range of flow cytometry and cell imaging reagents. Examine up to 30 parameters simultaneously with the ZE5 Cell Analyzer to distinguish subtly different cell populations, sort rare and single cells with the S3e Cell Sorter, and perform traditional immunocytochemistry and histochemical studies for biomarkers in live or fixed cells right at your bench with the ZOE Cell Imager.</p> <p><a href="/en-us/category/flow-cytometry">Cell Sorting and Flow Cytometry</a><br /> <a href="/en-us/product/flow-cytometry-antibodies">Antibodies for Flow Cytometry</a> <br /><a href="/en-us/category/cell-imaging">Cell Imaging</a><br /> <a href="/en-us/category/cell-counting">Cell Counting</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/antibodies.jpg" alt="Antibodies" /></p> </td> <td align="left" valign="top"> <h4>Antibodies</h4> <p style="margin-top: -7px;">Choose from an extensive range of antibodies for biomarker discovery assays, or utilize our custom antibody services and create your own.</p> <p>Antibody selection and antibody specificity are crucial to the performance of proteomic assays. Our <a href="https://www.bio-rad-antibodies.com/hucal-antibody-technology.html">HuCAL<sup>&reg;</sup> custom antibody technology</a> can generate highly specific custom human antibodies in only 8 weeks for a variety of applications, including flow cytometry, ELISA, and western blotting.</p> <p><a class="new-target-image" href="https://www.bio-rad-antibodies.com/antibody-applications.html" target="_blank" rel="noopener noreferrer">Antibodies by Application </a><br /> <a class="new-target-image" href="https://www.bio-rad-antibodies.com/clinical-diagnostic-antigens-and-antibodies.html">Antibodies for Diagnostic Assay Development </a><br /> <a class="new-target-image" href="https://www.bio-rad-antibodies.com/biotherapeutic-antibodies-drug-discovery.html">Antibodies for Drug Discovery and Development</a><br /> <a class="new-target-image" href="https://www.bio-rad-antibodies.com/custom-antibody-services.html" target="_blank" rel="noopener noreferrer">Custom Antibody Services </a></p> </td> </tr> </tbody> </table> <div class="videowrap"> <script src="http://admin.brightcove.com/js/BrightcoveExperiences.js" type="text/javascript"></script> <div class="videoImg"><a title="Bio-Plex Technology And Solutions Video" onclick="javascript:openAjaxOverlay('/webroot/web/html/lsr/products/bioplex_suspension_array/category_overlay/global/bio-plex_tech_and_testimonials_video.html' );" href="javascript:void(0);"><img style="border: none;" src="/webroot/web/images/lsr/solutions/applications/protein_functional_analysis/biomarker_analysis/application_detail/ov_bioplex_tech.jpg" alt="" /></a></div> <div class="videoDesc"><a title="Bio-Plex Technology And Solutions Video" onclick="javascript:openAjaxOverlay('/webroot/web/html/lsr/products/bioplex_suspension_array/category_overlay/global/bio-plex_tech_and_testimonials_video.html' );" href="javascript:void(0);"><br />Bio-Plex<sup>&reg;</sup> Technology And Solutions Video</a><br />Discover the capabilities of the Bio-Plex System: simultaneously quantify up to 500 proteins, peptides, and nucleic acid targets in a single sample. Assays for over 450 biologically relevant targets.</div> <div class="clear">&nbsp;</div> <script type="text/javascript">// <![CDATA[ brightcove.createExperiences(); // ]]></script> </div> <div class="videowrap"> <div class="videoImg"><a title="PrimePCR Assays in Breast Cancer Research" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);"><img style="width: 88px; height: 51px; border: 0;" src="/webroot/web/images/lsr/products/amplification_pcr/product_overlay_icons/global/using-primepcr-breast-cancer-thumb.jpg" alt="PrimePCR Cox2 Assay" /></a></div> <div class="videoDesc"><a title="PrimePCR Assays in Breast Cancer Research" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);">Using PrimePCR&trade; qPCR Assays to Understand Breast Cancer Metastasis</a> <br />Researchers at the University of Colorado use the PrimePCR Cox-2 Assay to verify cyclooxygenase-2 knockdown, a important step toward confirming its role in breast cancer metastasis.</div> <div class="clear">&nbsp;</div> </div> <div id="ovps01" style="display: none;"> <div class="overlay_contents" style="height: 410px;"> <div class="overlay-head">Using PrimePCR&trade; qPCR Assays to Understand Breast Cancer Metastasis</div> <iframe src="http://www.youtube.com/embed/6zv8PELHnGw?version=3&amp;rel=0&amp;showinfo=0&amp;theme=light&amp;modestbranding=1&amp;fs=1;wmode=transparent" width="620" height="349"></iframe> <br /> <p class="caption"><br />Traci Lyons describes how PrimePCR Assays ended her laboratory&rsquo;s struggle to find a qPCR assay that could reliably detect transcription of the cyclooxygenase-2 ( Cox-2) gene, which they had identified as potentially prometastatic.</p> </div> </div> <div class="videowrap"> <div class="videoImg"><a title="ZE5 Cell Analyzer" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);"><img style="width: 88px; height: 51px; border: 0;" src="/webroot/web/images/lsr/products/flow_cytometry/product_overlay_icons/global/lab-managers-perspective-thumb.jpg" alt="ZE5 Cell Analyzer" /></a></div> <div class="videoDesc"><a title="ZE5 Cell Analyzer" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);">A Core Lab Manager's Perspective on Bio-Rad's ZE5&trade; Cell Analyzer</a> <br />A Flow Cytometry Core Lab manager describes her experience using the ZE5 Cell Analyzer.</div> <div class="clear">&nbsp;</div> </div> <div id="ovps01" style="display: none;"> <div class="overlay_contents" style="height: 410px;"> <div class="overlay-head">Introducing the ZE5&trade; Cell Analyzer</div> <iframe src="http://www.youtube.com/embed/6P66yAPglsE?version=3&amp;rel=0&amp;showinfo=0&amp;theme=light&amp;modestbranding=1&amp;fs=1;wmode=transparent" width="620" height="349"></iframe> <br /> <p class="caption"><br />Flow Cytometry Core Lab Manager Karen Helm at the University of Colorado Cancer Center discusses her experience using Bio-Rad's ZE5 Flow Cytometer.</p> </div> </div> <div class="videowrap"> <div class="videoImg"><a title="S3e Cell Sorter" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);"><img style="width: 88px; height: 51px; border: 0;" src="/webroot/web/images/lsr/products/flow_cytometry/product_overlay_icons/global/affordable-cell-scorting-thumb.jpg" alt="S3e Cell Sorter" /></a></div> <div class="videoDesc"><a title="S3e Cell Sorter" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);">Bio-Rad's S3e&trade; Cell Sorter</a> <br />Automated, affordable cell sorting for drug discovery &amp; development with the S3e Cell Sorter</div> <div class="clear">&nbsp;</div> </div> <div id="ovps01" style="display: none;"> <div class="overlay_contents" style="height: 410px;"> <div class="overlay-head">Bio-Rad's S3e&trade; Cell Sorter</div> <iframe src="http://www.youtube.com/embed/uKg1tyhXlrM?version=3&amp;rel=0&amp;showinfo=0&amp;theme=light&amp;modestbranding=1&amp;fs=1;wmode=transparent" width="620" height="349"></iframe> <br /> <p class="caption"><br />The S3e System is an automated benchtop cell sorter featuring either one or two lasers and up to four fluorescence detectors plus forward- and side-scatter detectors. The first truly walk-up cell sorter, the S3e Cell Sorter delivers an easy-to-use, affordable solution for busy scientists.</p> </div> </div> 7048 templatedata/internet/documentation/data/LSR/Literature/7048_1520465234.xml Understanding Biomarkers for Better Drug Discovery and Development 7048 /webroot/web/pdf/lsr/literature/Bulletin_7048.pdf Literature PDF Articles_and_Whitepapers Understanding Biomarkers for Better Drug Discovery and Development No Understanding Biomarkers for Better Drug Discovery and Development 7048 7048, Understanding Biomarkers for Better Drug Discovery and Development 6959 templatedata/internet/documentation/data/LSR/Literature/6959_1524088332.xml Biomarker Workflow Solutions Brochure, Rev A 6959 /webroot/web/pdf/lsr/literature/Bulletin_6959.pdf Literature PDF Brochures_and_Specifications /webroot/web/images/general/icons/icon_pdf.gif No Biomarker Workflow Solutions Brochure, Rev A 6959 biomarkers, biomarker development, biomarker validation 6516 templatedata/internet/documentation/data/LSR/Literature/6516_1399508224.xml Better, Faster, and Less Expensive Gene Expression Analysis Using Multiplex One-Step RT-qPCR: A Case Study of Colorectal Cancer, Rev A 6516 /webroot/web/pdf/lsr/literature/Bulletin_6516.pdf Literature PDF Application_Notes /webroot/web/images/general/icons/icon_pdf.gif Better, Faster, and Less Expensive Gene Expression Analysis Using Multiplex One-Step RT-qPCR: A Case Study of Colorectal Cancer, Rev A No Better, Faster, and Less Expensive Gene Expression Analysis Using Multiplex One-Step RT-qPCR: A Case Study of Colorectal Cancer, Rev A 6516 6516, assay validation, biomarkers, colorectal cancer, gene expression, iTaq universal probes one-step kit, multiplex analysis, monitoring CRC neoplasms, one-step RT-qPCR, qPCR, reverse transcription quantitative PCR, RT-qPCR, triplex assay, 172-5140, 1725140, 172-5141, 1725141 5590 /templatedata/internet/documentation/data/LSR/Literature/5590_0910141007685.xml 5590 Detection of Genetic Abnormalities in Cancer Cells Using Bio-Plex Immunoassays, Rev A /webroot/web/pdf/lsr/literature/bulletin_5590.pdf Literature PDF Application_Notes /webroot/web/images/general/icons/icon_pdf.gif No Detection of Genetic Abnormalities in Cancer Cells Using Bio-Plex Immunoassays, Rev A Life Science 5590 171-000201, 171-000205, Bcr isoforms, Bio Plex Immuno-assays, CST, suspension array system, capture antibody, EGFR signal transduction, proteins, tyrosine kinase signaling, 171000201, Bcr-Abl translocations, c-Abl, CML, chronic myelogenous leukemia, myeloid, 171000205, fusion protein, L858R point mutation, LIT5590, beads Karen Moss Biomarker Discovery Learn about biomarker discovery in drug discovery & development. drug discovery, discovery, drug development, development, pharma, pharmaceutical, biomarker discovery 10/06/15 04:04 PM 10/06/25 04:06 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Applications/Drug_Discovery N 0 Drug Discovery and Development /en-us/applications-technologies/applications-technologies/biomarker-discovery-validation?ID=NU4EE515
Biomarker Discovery and Validation

 

Biomarker Discovery
Biomarkers provide vital information regarding safety and efficacy during drug discovery and development. They are loosely defined as diagnostic, prognostic, or predictive and can be used to select patients for clinical trials or monitor patient response and treatment efficacy. In addition, after regulatory approval, biomarkers can be used to identify patient populations that would benefit from a particular therapy along with continuing to monitor the treatment’s efficacy. Show more

Biomarkers are used in research to design and develop more effective therapeutics, to assist in guiding decisions about which candidates to develop further, as surrogate markers for the selection of patients, and as endpoints for both benefits and risks. There are a wide range of types of biomarkers that can be monitored, such as predictive, prognostic, pharmacodynamic, safety, and efficacy markers. One class of biomarkers that is actively being researched is safety biomarkers. These markers are being developed to help determine which drug candidates are most likely to be safely tolerated in humans.

From Discovery to Validation
Biomarkers range from specific molecules such as a protein, gene sequence, or expressed RNA to physiological parameters such as blood pressure or body temperature. They may be expressed in a specific location or tissue or found in serum, plasma, and other bodily fluids. Because of this diversity, most successful biomarker programs have a broad reach and investigate cellular, proteomic, and genetic sources in order to find the most valuable biomarkers.

Validation of biomarkers requires that their levels change in response to a disease, condition, or other parameter in a consistent and statistically significant manner. Identification and characterization of biomarkers can reduce the number of candidate drugs that fail clinical trials, aid in the discovery of more effective therapeutics, and provide methods for monitoring animals in preclinical research and evaluating the response of human participants in clinical trials.

Genomic Biomarkers
Both gene expression and the presence of specific genetic sequences are used as biomarkers for many diseases including cancer. Treatments can even be tailored to an individual patient based on these genomic biomarkers. Typically, large-scale gene expression studies are conducted to identify genes that are up- or down-regulated in a particular indication or disease. These studies rely on the ability of the researchers to design exploratory and confirmatory panels as well as on powerful software tools to analyze resulting data and identify potential biomarkers.

Proteomic Biomarkers
Interrogating biological samples to identify proteomic profiles gives rise to a plethora of potential biomarkers. Proteins are vital, functional parts of living organisms and as such reflect what is happening in that organism. Monitoring the post-translational state of proteins of interest can yield important biomarkers and indicate tumor progression.

Cellular Biomarkers
The ability to uncover novel and rare cell types through multiparameter analysis allows researchers to characterize cell populations in greater detail and identify subpopulations that serve as markers for disease. Simple and reliable isolation of these cells for downstream assays further supports the cellular biomarker workflow by providing pure populations for genomic and proteomic analysis. Show less

 

Cell Sorting for Drug DiscoveryFeatured Video
Automated, Affordable Cell Sorting for Drug Discovery & Development with the S3e™ Cell Sorter

 

 
 
Page Contents
 
 
 

Solutions for Biomarker Discovery

Gene Expression

Gene Expression

Select from a range of validated PCR, qPCR, and digital PCR instruments to incorporate into your biomarker research. Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.

CFX Real-Time PCR Detection Systems along with predesigned or custom-built or predesigned PrimePCR™ Panels for pathway or disease state targets allow you to measure multiple genes from multiple samples at once sourced from liquid biopsy, tissue, or cell based materials. Coupled with the CFX Automation System II, up to 48 plates can be read unattended. If increased sensitivity is required, such as for the detection and quantification of CTCs and rare cancer mutations, the QX200 Droplet Digital PCR (ddPCR™) System is an ideal choice, as it allows detection of rare, low-abundance genetic biomarkers. Both systems are provided with IQ/OQ workflows and tools that enable 21 CFR Part 11 compliance.

Real-Time PCR Detection Systems
Droplet Digital™ PCR Systems
ddPCR™ Supermixes for Residual DNA Quantification

PCR Instrument Validation Tools and Services

 

Protein Expression, Quantitation, and Analysis

Protein Expression, Quantitation, and Analysis

Analyze the expression of biomarkers in complex backgrounds with multiplex immunoassays, 1-D and 2-D electrophoresis, and western blotting.

The V3 Western Workflow™ is a validated and streamlined workflow suite that allows faster quantitation of protein expression with more accuracy than other western blotting systems. By incorporating the ChemiDoc™ MP Imaging System, this workflow allows simultaneous analysis of up to three proteins via multiplex fluorescent western blotting. Bio-Plex Multiplex Immunoassay Systems and Assays allow analysis of large numbers of biomarkers in a single experiment. Predesigned panels for a given indication remove the guesswork from your search, while custom assays allow you to design panels for your unique markers as your biomarker program progresses.

Multiplex Cell Signaling Immunoassays
Multiplex Cancer Biomarker Immunoassays
Multiplex Kidney Toxicity Immunoassays
Custom Multiplex Immunoassays
2-D Electrophoresis Systems
V3 Western Workflow
Stain-Free Gel and Western Blot Imaging Systems

Cell Analysis

Cell Analysis

Bio-Rad offers equipment and reagents for cell-based biomarker evaluation and measurement.

Our comprehensive and easy-to-use suite of cell analysis products includes the ZE5™ Cell Analyzer, the S3e™ Cell Sorter, and the ZOE™ Fluorescent Cell Imager, and includes a wide range of flow cytometry and cell imaging reagents. Examine up to 30 parameters simultaneously with the ZE5 Cell Analyzer to distinguish subtly different cell populations, sort rare and single cells with the S3e Cell Sorter, and perform traditional immunocytochemistry and histochemical studies for biomarkers in live or fixed cells right at your bench with the ZOE Cell Imager.

Cell Sorting and Flow Cytometry
Antibodies for Flow Cytometry
Cell Imaging
Cell Counting

Antibodies

Antibodies

Choose from an extensive range of antibodies for biomarker discovery assays, or utilize our custom antibody services and create your own.

Antibody selection and antibody specificity are crucial to the performance of proteomic assays. Our HuCAL® custom antibody technology can generate highly specific custom human antibodies in only 8 weeks for a variety of applications, including flow cytometry, ELISA, and western blotting.

Antibodies by Application
Antibodies for Diagnostic Assay Development
Antibodies for Drug Discovery and Development
Custom Antibody Services

 

Related Content

 

Bio-Plex® Technology And Solutions Video

Discover the capabilities of the Bio-Plex System: simultaneously quantify up to 500 proteins, peptides, and nucleic acid targets in a single sample. Assays for over 450 biologically relevant targets.
 
PrimePCR Cox2 Assay
Using PrimePCR™ qPCR Assays to Understand Breast Cancer Metastasis
Researchers at the University of Colorado use the PrimePCR Cox-2 Assay to verify cyclooxygenase-2 knockdown, a important step toward confirming its role in breast cancer metastasis.
 
ZE5 Cell Analyzer
A Core Lab Manager's Perspective on Bio-Rad's ZE5™ Cell Analyzer
A Flow Cytometry Core Lab manager describes her experience using the ZE5 Cell Analyzer.
 
S3e Cell Sorter
Bio-Rad's S3e™ Cell Sorter
Automated, affordable cell sorting for drug discovery & development with the S3e Cell Sorter
 
Literature
Number Description Download
7048 Understanding Biomarkers for Better Drug Discovery and Development Click to download
6959 Biomarker Workflow Solutions Brochure, Rev A Click to download
6516 Better, Faster, and Less Expensive Gene Expression Analysis Using Multiplex One-Step RT-qPCR: A Case Study of Colorectal Cancer, Rev A Click to download
5590 Detection of Genetic Abnormalities in Cancer Cells Using Bio-Plex Immunoassays, Rev A Click to download
 
 
NU4F7VMNI [x-forwarded-proto] = [http] [x-forwarded-port] = [80] [x-forwarded-for] = [54.224.11.137, 10.232.3.215] [accept] = [text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8] [seourl] = [/en-us/applications-technologies/biomarker-discovery-validation] [x-amzn-trace-id] = [Root=1-5b7577f0-2caedf904618716e5e64c2e2] [x-forwarded-server] = [lsds-prod-s.br.aws-livesite.io] [x-forwarded-host] = [www.bio-rad.com] [x-query-string] = [ID=NU4F7VMNI] [host] = [10.232.17.28:1776] [x-request-uri] = [/en-us/applications-technologies/biomarker-discovery-validation] [connection] = [Keep-Alive] [accept-encoding] = [gzip] [user-agent] = [CCBot/2.0 (https://commoncrawl.org/faq/)] AppTech/AppTechDetails pageStyleKey internet/solutions_sub applications-technologies/biomarker-discovery-validation LSR NU4F7VMNI Biomarker Discovery Biomarker Discovery and Validation /webroot/web/html/lsr/solutions/applications/drug_discovery <script type="text/javascript">// <![CDATA[ $(document).ready(function(){ $('.pagecontent2').hide(); $(".content-show").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:0}, 500); }); $(".content-hide").click(function(){ $(".content-more").slideToggle(200); $(".content-hide").toggle(); $(".content-show").animate({opacity:100}, 800); }); }); // ]]></script> <div class="ddflow-container"> <ul class="ddflow"> <li class="ddflow-on"><a href="/en-us/applications-technologies/target-discovery-identification-validation">Target <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-target-discovery.jpg" alt="Target Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/lead-discovery-screening-optimization">Lead <br />Discovery<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-lead-discovery.jpg" alt="Lead Discovery" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/preclinical-research">Preclinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-preclinical-research.jpg" alt="Preclinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/clinical-research">Clinical <br />Research<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-clincal-research.jpg" alt="Clinical Research" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li class="ddflow-on"><a href="/en-us/applications-technologies/process-development-scale">Process <br />Development<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-process-development.jpg" alt="Process Development" /></div> </a></li> <li class="dd-arrow">&nbsp;</li> <li>&nbsp;<br /><a href="/en-us/applications-technologies/pharmaceutical-manufacturing-release-testing">Manufacturing<br /> <div><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/workflow-manufacturing.jpg" alt="Pharmaceutical Manufacturing and Release Testing" /></div> </a></li> </ul> </div> <div class="ddflow-othr-container ddflow-othr-container-biomarker"> <div class="ddflow-othr-biomarker"> <div class="ddflow-othr-main ddflow-biomarker">Biomarker Discovery and Validation</div> </div> </div> <br style="clear: both;" />&nbsp; <p><strong>Biomarker Discovery</strong><br />Biomarkers provide vital information regarding safety and efficacy during drug discovery and development. They are loosely defined as diagnostic, prognostic, or predictive and can be used to select patients for clinical trials or monitor patient response and treatment efficacy. In addition, after regulatory approval, biomarkers can be used to identify patient populations that would benefit from a particular therapy along with continuing to monitor the treatment&rsquo;s efficacy. <span class="content-show"> Show more</span></p> <p class="content-more">Biomarkers are used in research to design and develop more effective therapeutics, to assist in guiding decisions about which candidates to develop further, as surrogate markers for the selection of patients, and as endpoints for both benefits and risks. There are a wide range of types of biomarkers that can be monitored, such as predictive, prognostic, pharmacodynamic, safety, and efficacy markers. One class of biomarkers that is actively being researched is safety biomarkers. These markers are being developed to help determine which drug candidates are most likely to be safely tolerated in humans.</p> <p class="content-more"><strong>From Discovery to Validation</strong><br /> Biomarkers range from specific molecules such as a protein, gene sequence, or expressed RNA to physiological parameters such as blood pressure or body temperature. They may be expressed in a specific location or tissue or found in serum, plasma, and other bodily fluids. Because of this diversity, most successful biomarker programs have a broad reach and investigate cellular, proteomic, and genetic sources in order to find the most valuable biomarkers.</p> <p class="content-more">Validation of biomarkers requires that their levels change in response to a disease, condition, or other parameter in a consistent and statistically significant manner. Identification and characterization of biomarkers can reduce the number of candidate drugs that fail clinical trials, aid in the discovery of more effective therapeutics, and provide methods for monitoring animals in preclinical research and evaluating the response of human participants in clinical trials.</p> <p class="content-more"><strong>Genomic Biomarkers</strong><br /> Both gene expression and the presence of specific genetic sequences are used as biomarkers for many diseases including cancer. Treatments can even be tailored to an individual patient based on these genomic biomarkers. Typically, large-scale gene expression studies are conducted to identify genes that are up- or down-regulated in a particular indication or disease. These studies rely on the ability of the researchers to design exploratory and confirmatory panels as well as on powerful software tools to analyze resulting data and identify potential biomarkers.</p> <p class="content-more"><strong>Proteomic Biomarkers</strong><br /> Interrogating biological samples to identify proteomic profiles gives rise to a plethora of potential biomarkers. Proteins are vital, functional parts of living organisms and as such reflect what is happening in that organism. Monitoring the post-translational state of proteins of interest can yield important biomarkers and indicate tumor progression.</p> <p class="content-more"><strong>Cellular Biomarkers</strong><br /> The ability to uncover novel and rare cell types through multiparameter analysis allows researchers to characterize cell populations in greater detail and identify subpopulations that serve as markers for disease. Simple and reliable isolation of these cells for downstream assays further supports the cellular biomarker workflow by providing pure populations for genomic and proteomic analysis. <span class="content-hide">Show less</span></p> &nbsp; <p><a href="javascript:openAjaxOverlay(&quot;/webroot/web/html/lsr/solutions/applications/drug_discovery/ov-cell-sorting-drug-discovery-development-video.html&quot;);"><img style="float: left; margin-right: 10px;" src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-sorting-for-drug-discovery-development-video.jpg" alt="Cell Sorting for Drug Discovery" width="79" height="45" /><strong>Featured Video</strong></a><br />Automated, Affordable Cell Sorting for Drug Discovery &amp; Development with the S3e&trade; Cell Sorter</p> <p>&nbsp;</p> Solutions for Biomarker Discovery <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/gene-expression.jpg" alt="Gene Expression" /></p> </td> <td align="left" valign="top"> <h4>Gene Expression</h4> <p style="margin-top: -7px;">Select from a range of validated PCR, qPCR, and digital PCR instruments to incorporate into your biomarker research. Explore our large library of disease-specific and pathway-specific predesigned PCR primers, probes, and assay panels that meet MIQE guidelines, or order custom-designed primers and plates.</p> <p>CFX Real-Time PCR Detection Systems along with predesigned or custom-built or predesigned PrimePCR&trade; Panels for pathway or disease state targets allow you to measure multiple genes from multiple samples at once sourced from liquid biopsy, tissue, or cell based materials. Coupled with the CFX Automation System II, up to 48 plates can be read unattended. If increased sensitivity is required, such as for the detection and quantification of CTCs and rare cancer mutations, the QX200 Droplet Digital PCR (ddPCR&trade;) System is an ideal choice, as it allows detection of rare, low-abundance genetic biomarkers. Both systems are provided with IQ/OQ workflows and tools that enable 21 CFR Part 11 compliance.</p> <p><a href="/en-us/category/real-time-pcr-detection-systems">Real-Time PCR Detection Systems</a><br /><a href="/en-us/category/digital-pcr">Droplet Digital&trade; PCR Systems</a><br /> <a href="/en-us/product/residual-dna-quantification-supermixes">ddPCR&trade; Supermixes for Residual DNA Quantification</a></p> <div id="pcrPrimersprobesassaysLink" style="margin: -10px 0 -0px 0;"> <script type="text/javascript">// <![CDATA[ $('#pcrPrimersprobesassaysLink').load('/webroot/web/html/lsr/products/amplification_pcr/pcr-primers-probes-assays-link.html'); // ]]></script> </div> <a style="font-size: 12px;" href="/en-us/category/pcr-instrument-validation-tools-services">PCR Instrument Validation Tools and Services</a> <p>&nbsp;</p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/protein-expression-quantitation-analysis.jpg" alt="Protein Expression, Quantitation, and Analysis" /></p> </td> <td align="left" valign="top"> <h4>Protein Expression, Quantitation, and Analysis</h4> <p style="margin-top: -7px;">Analyze the expression of biomarkers in complex backgrounds with multiplex immunoassays, 1-D and 2-D electrophoresis, and western blotting.</p> <p>The V3 Western Workflow&trade; is a validated and streamlined workflow suite that allows faster quantitation of protein expression with more accuracy than other western blotting systems. By incorporating the ChemiDoc&trade; MP Imaging System, this workflow allows simultaneous analysis of up to three proteins via multiplex fluorescent western blotting. Bio-Plex Multiplex Immunoassay Systems and Assays allow analysis of large numbers of biomarkers in a single experiment. Predesigned panels for a given indication remove the guesswork from your search, while custom assays allow you to design panels for your unique markers as your biomarker program progresses.</p> <p><a href="/en-us/category/cell-signaling-assays">Multiplex Cell Signaling Immunoassays</a><br /> <a href="/en-us/product/bio-plex-pro-human-cancer-biomarker-assays">Multiplex Cancer Biomarker Immunoassays </a><br /> <a href="/en-us/category/kidney-toxicity-assays">Multiplex Kidney Toxicity Immunoassays </a><br /> <a href="/en-us/bio-plex-assay-builder">Custom Multiplex Immunoassays </a><br /> <a href="/en-us/category/2-d-electrophoresis">2-D Electrophoresis Systems</a><br /> <a href="/en-us/product/v3-western-workflow">V3 Western Workflow</a><br /> <a href="/en-us/category/gel-imaging-systems">Stain-Free Gel and Western Blot Imaging Systems</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr style="border-bottom: 2px dotted #cccccc; width: 597px;"> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/cell-analysis.jpg" alt="Cell Analysis" /></p> </td> <td align="left" valign="top"> <h4>Cell Analysis</h4> <p style="margin-top: -7px;">Bio-Rad offers equipment and reagents for cell-based biomarker evaluation and measurement.</p> <p>Our comprehensive and easy-to-use suite of cell analysis products includes the ZE5&trade; Cell Analyzer, the S3e&trade; Cell Sorter, and the ZOE&trade; Fluorescent Cell Imager, and includes a wide range of flow cytometry and cell imaging reagents. Examine up to 30 parameters simultaneously with the ZE5 Cell Analyzer to distinguish subtly different cell populations, sort rare and single cells with the S3e Cell Sorter, and perform traditional immunocytochemistry and histochemical studies for biomarkers in live or fixed cells right at your bench with the ZOE Cell Imager.</p> <p><a href="/en-us/category/flow-cytometry">Cell Sorting and Flow Cytometry</a><br /> <a href="/en-us/product/flow-cytometry-antibodies">Antibodies for Flow Cytometry</a> <br /><a href="/en-us/category/cell-imaging">Cell Imaging</a><br /> <a href="/en-us/category/cell-counting">Cell Counting</a></p> </td> </tr> </tbody> </table> <table class="pd_table" border="0"> <tbody> <tr> <td align="left" valign="top"> <p style="margin-top: 0px;"><img src="/webroot/web/images/lsr/solutions/applications/drug_discovery/antibodies.jpg" alt="Antibodies" /></p> </td> <td align="left" valign="top"> <h4>Antibodies</h4> <p style="margin-top: -7px;">Choose from an extensive range of antibodies for biomarker discovery assays, or utilize our custom antibody services and create your own.</p> <p>Antibody selection and antibody specificity are crucial to the performance of proteomic assays. Our <a href="https://www.bio-rad-antibodies.com/hucal-antibody-technology.html">HuCAL<sup>&reg;</sup> custom antibody technology</a> can generate highly specific custom human antibodies in only 8 weeks for a variety of applications, including flow cytometry, ELISA, and western blotting.</p> <p><a class="new-target-image" href="https://www.bio-rad-antibodies.com/antibody-applications.html" target="_blank" rel="noopener noreferrer">Antibodies by Application </a><br /> <a class="new-target-image" href="https://www.bio-rad-antibodies.com/clinical-diagnostic-antigens-and-antibodies.html">Antibodies for Diagnostic Assay Development </a><br /> <a class="new-target-image" href="https://www.bio-rad-antibodies.com/biotherapeutic-antibodies-drug-discovery.html">Antibodies for Drug Discovery and Development</a><br /> <a class="new-target-image" href="https://www.bio-rad-antibodies.com/custom-antibody-services.html" target="_blank" rel="noopener noreferrer">Custom Antibody Services </a></p> </td> </tr> </tbody> </table> <div class="videowrap"> <script src="http://admin.brightcove.com/js/BrightcoveExperiences.js" type="text/javascript"></script> <div class="videoImg"><a title="Bio-Plex Technology And Solutions Video" onclick="javascript:openAjaxOverlay('/webroot/web/html/lsr/products/bioplex_suspension_array/category_overlay/global/bio-plex_tech_and_testimonials_video.html' );" href="javascript:void(0);"><img style="border: none;" src="/webroot/web/images/lsr/solutions/applications/protein_functional_analysis/biomarker_analysis/application_detail/ov_bioplex_tech.jpg" alt="" /></a></div> <div class="videoDesc"><a title="Bio-Plex Technology And Solutions Video" onclick="javascript:openAjaxOverlay('/webroot/web/html/lsr/products/bioplex_suspension_array/category_overlay/global/bio-plex_tech_and_testimonials_video.html' );" href="javascript:void(0);"><br />Bio-Plex<sup>&reg;</sup> Technology And Solutions Video</a><br />Discover the capabilities of the Bio-Plex System: simultaneously quantify up to 500 proteins, peptides, and nucleic acid targets in a single sample. Assays for over 450 biologically relevant targets.</div> <div class="clear">&nbsp;</div> <script type="text/javascript">// <![CDATA[ brightcove.createExperiences(); // ]]></script> </div> <div class="videowrap"> <div class="videoImg"><a title="PrimePCR Assays in Breast Cancer Research" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);"><img style="width: 88px; height: 51px; border: 0;" src="/webroot/web/images/lsr/products/amplification_pcr/product_overlay_icons/global/using-primepcr-breast-cancer-thumb.jpg" alt="PrimePCR Cox2 Assay" /></a></div> <div class="videoDesc"><a title="PrimePCR Assays in Breast Cancer Research" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);">Using PrimePCR&trade; qPCR Assays to Understand Breast Cancer Metastasis</a> <br />Researchers at the University of Colorado use the PrimePCR Cox-2 Assay to verify cyclooxygenase-2 knockdown, a important step toward confirming its role in breast cancer metastasis.</div> <div class="clear">&nbsp;</div> </div> <div id="ovps01" style="display: none;"> <div class="overlay_contents" style="height: 410px;"> <div class="overlay-head">Using PrimePCR&trade; qPCR Assays to Understand Breast Cancer Metastasis</div> <iframe src="http://www.youtube.com/embed/6zv8PELHnGw?version=3&amp;rel=0&amp;showinfo=0&amp;theme=light&amp;modestbranding=1&amp;fs=1;wmode=transparent" width="620" height="349"></iframe> <br /> <p class="caption"><br />Traci Lyons describes how PrimePCR Assays ended her laboratory&rsquo;s struggle to find a qPCR assay that could reliably detect transcription of the cyclooxygenase-2 ( Cox-2) gene, which they had identified as potentially prometastatic.</p> </div> </div> <div class="videowrap"> <div class="videoImg"><a title="ZE5 Cell Analyzer" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);"><img style="width: 88px; height: 51px; border: 0;" src="/webroot/web/images/lsr/products/flow_cytometry/product_overlay_icons/global/lab-managers-perspective-thumb.jpg" alt="ZE5 Cell Analyzer" /></a></div> <div class="videoDesc"><a title="ZE5 Cell Analyzer" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);">A Core Lab Manager's Perspective on Bio-Rad's ZE5&trade; Cell Analyzer</a> <br />A Flow Cytometry Core Lab manager describes her experience using the ZE5 Cell Analyzer.</div> <div class="clear">&nbsp;</div> </div> <div id="ovps01" style="display: none;"> <div class="overlay_contents" style="height: 410px;"> <div class="overlay-head">Introducing the ZE5&trade; Cell Analyzer</div> <iframe src="http://www.youtube.com/embed/6P66yAPglsE?version=3&amp;rel=0&amp;showinfo=0&amp;theme=light&amp;modestbranding=1&amp;fs=1;wmode=transparent" width="620" height="349"></iframe> <br /> <p class="caption"><br />Flow Cytometry Core Lab Manager Karen Helm at the University of Colorado Cancer Center discusses her experience using Bio-Rad's ZE5 Flow Cytometer.</p> </div> </div> <div class="videowrap"> <div class="videoImg"><a title="S3e Cell Sorter" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);"><img style="width: 88px; height: 51px; border: 0;" src="/webroot/web/images/lsr/products/flow_cytometry/product_overlay_icons/global/affordable-cell-scorting-thumb.jpg" alt="S3e Cell Sorter" /></a></div> <div class="videoDesc"><a title="S3e Cell Sorter" onclick="javascript:openElementOverlay('ovps01');" href="javascript:void(0);">Bio-Rad's S3e&trade; Cell Sorter</a> <br />Automated, affordable cell sorting for drug discovery &amp; development with the S3e Cell Sorter</div> <div class="clear">&nbsp;</div> </div> <div id="ovps01" style="display: none;"> <div class="overlay_contents" style="height: 410px;"> <div class="overlay-head">Bio-Rad's S3e&trade; Cell Sorter</div> <iframe src="http://www.youtube.com/embed/uKg1tyhXlrM?version=3&amp;rel=0&amp;showinfo=0&amp;theme=light&amp;modestbranding=1&amp;fs=1;wmode=transparent" width="620" height="349"></iframe> <br /> <p class="caption"><br />The S3e System is an automated benchtop cell sorter featuring either one or two lasers and up to four fluorescence detectors plus forward- and side-scatter detectors. The first truly walk-up cell sorter, the S3e Cell Sorter delivers an easy-to-use, affordable solution for busy scientists.</p> </div> </div> 7048 templatedata/internet/documentation/data/LSR/Literature/7048_1520465234.xml 6959 templatedata/internet/documentation/data/LSR/Literature/6959_1524088332.xml 6516 templatedata/internet/documentation/data/LSR/Literature/6516_1399508224.xml 5590 /templatedata/internet/documentation/data/LSR/Literature/5590_0910141007685.xml Karen Moss Biomarker Discovery Learn about biomarker discovery in drug discovery & development. drug discovery, discovery, drug development, development, pharma, pharmaceutical, biomarker discovery 10/06/15 04:04 PM 10/06/25 04:06 PM AE,AI,AL,AM,AR,AT,AU,AZ,BA,BD,BE,BF,BG,BH,BN,BO,BR,BW,CA,CH,CL,CM,CN,CO,CR,CY,CZ,DE,DK,DO,DZ,EC,EE,EG,EH,ER,ES,ET,FI,FM,FO,FR,GA,GE,GF,GH,GP,GR,GT,GU,HK,HN,HR,HT,HU,ID,IE,IL,IN,IS,IT,JM,JO,JP,KE,KH,KR,KW,KZ,LB,LI,LK,LT,LU,LV,MA,MD,MG,MK,ML,MO,MQ,MS,MT,MU,MX,MY,NG,NI,NL,NO,NP,NZ,OM,PA,PE,PF,PG,PH,PK,PL,PR,PS,PT,PW,PY,QA,RO,RS,RU,SA,SB,SE,SG,SI,SK,SN,ST,SV,TG,TH,TN,TO,TR,TT,TW,TZ,UA,UG,UK,US,UY,UZ,VA,VE,VU,XK,YE,ZA en LSR /LSR/Applications/Drug_Discovery N 0
Sign Up for Bio-Rad Updates!
Enter your email address below to receive your choice of the latest news, promotions, and more.