Bio-Plex Pro™ RBM Rat Kidney Toxicity Assays

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Bio-Plex Pro RBM Rat Kidney Toxicity Assays - Bio-Plex Pro RBM Kidney Toxicity Assays

Overview

Available Bio-Plex Pro™ RBM Rat Kidney Toxicity Assays
Rat Kidney Toxicity Panel 1
(171-KTR1CK)
Analyte Bead Region
Clusterin 12
IL-18 21
KIM-1 20
MCP-1 15
Osteopontin 52
Rat Kidney Toxicity Panel 2
(171-KTR2CK)
Analyte Bead Region
B2M 22
Calbindin 62
Cystatin C 44
NGAL 46
Rat Kidney Toxicity Albumin Kit
(171-KTR3CK)
Analyte Bead Region
Albumin 30
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Bio-Plex® Technology and Applications

The Bio-Plex Pro RBM kidney toxicity assays, developed in partnership with Myriad RBM, comprise a highly relevant set of biomarkers for early detection and characterization of kidney toxicity/injury. Myriad RBM’s close collaboration with the Predictive Safety Testing Consortium (PSTC), FDA, and European Medicines Evaluation Agency (EMEA) was instrumental in the selection of markers found in these panels.

The assays are built on magnetic beads to enable robust quantification of multiple proteins in rat urine samples, providing valuable information throughout drug development — from lead optimization to preclinical and clinical protocol decision making. Assays are offered as premixed all-in-one kits for research involving:

  • Drug-induced kidney toxicity
  • Diabetes
  • High blood pressure
  • Glomerulonephritis
  • Polycystic kidney disease
  • Chronic infection
  • SLE (lupus) and other autoimmune disorders

Bio-Plex Pro RBM rat kidney toxicity assays are available as two panels and an albumin kit:

    Panel 1
  • Clusterin
  • IL-18
  • KIM-1
  • MCP-1
  • Osteopontin
    Panel 2
  • B2M
  • Calbindin
  • Cystatin C
  • NGAL
    Albumin Kit
  • Albumin

Based on 6.5 µm magnetic beads, these assay panels are compatible with both vacuum and magnetic wash stations. Magnetic washing simplifies plate processing, provides increased throughput, and results in decreased variability and increased reproducibility.

Key Features

  • Optimized for high precision and lot-to-lot reproducibility of sample measurements
  • Magnetic beads for simplified plate processing
  • 2-level quality controls with lot-specific ranges
  • Assay quick guide to get you started right away
  • High-quality design ensures robust and reproducible measurement of nephrotoxicity biomarkers in human, rat, and canine urine samples

Ordering Options

Premixed all-in-one kits

Instrument Compatibility

More Information

See how Bio-Plex instruments and assays benefit researchers studying heart disease, leukemia, melanoma, and other cancers.

Number Description Options
6458 Bio-Plex Success Guide/Assay Sample Prep, Rev B Click to download
6335 Bio-Plex® Multiplex Immunoassays Analyte Guide, Interactive PDF, Rev D Click to download
10028258 Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays, Rev A Click to download
10028259 Instruction Manual, Bio-Plex Pro RBM Kidney Toxicity Assays Quick Guide, Rev B Click to download
6347 Bio-Plex Pro RBM Assays Product Information Sheet, Rev A Click to download
6400 Profiling of Human, Canine, and Rat Urine Samples Using Bio-Plex Pro RBM Kidney Toxicity Assay, Rev A Click to download